Mosaicism—the existence of genetically distinct populations of cells in a particular organism—
is an important cause of genetic disease. Mosaicism can appear as de novo DNA mutations …

Human germline de novo mutations (DNMs) are both a driver of evolution and an important
cause of genetic diseases. In the past few years, whole-genome sequencing (WGS) of …

Spermatogonial stem cells (SSCs) are the basis of spermatogenesis, and any damage to
SSCs may result in spermatogenic disorder and male infertility. Chromium (Cr)(VI) is a …

Currently, most men with infertility cannot be given an aetiology, which reflects a lack of
knowledge around gamete production and how it is affected by genetics and the …

The spermatozoon is a highly differentiated and polarized cell, with two main structures: the
head, containing a haploid nucleus and the acrosomal exocytotic granule, and the flagellum …

Spermatogonial stem cells (SSCs) are essential for long-term spermatogenesis and are the
subject of considerable clinical interest, as 'SSC therapy'has the potential to cure some …

The amount of single-cell RNA-sequencing (scRNA-seq) data produced in the field of
human male reproduction has steadily increased. Transcriptional profiles of thousands of …

Abstract Infertility affects 8–12% of couples globally, and the male factor is a primary cause
in~ 50% of couples. Male infertility is a multifactorial reproductive disorder, which can be …

Background Spermatogenesis is an intricate developmental process during which
undifferentiated spermatogonia, containing spermatogonial stem cells (SSCs), undergo self …

STUDY QUESTION What is the molecular landscape underlying the functional decline of
human testicular ageing? SUMMARY ANSWER The present study provides a …