NF-κB: at the borders of autoimmunity and inflammation
L Barnabei, E Laplantine, W Mbongo… - Frontiers in …, 2021 - frontiersin.org
The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune
functions and serves as a pivotal mediator of inflammatory response. In the first part of this …
functions and serves as a pivotal mediator of inflammatory response. In the first part of this …
Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study
H Yu, L Lin, Z Zhang, H Zhang, H Hu - Signal transduction and targeted …, 2020 - nature.com
NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is
activated by various stimuli, transducing a quick but transient transcriptional activity, to …
activated by various stimuli, transducing a quick but transient transcriptional activity, to …
Primary immune regulatory disorders with an autoimmune lymphoproliferative syndrome-like phenotype: immunologic evaluation, early diagnosis and management
M López-Nevado, LI González-Granado… - Frontiers in …, 2021 - frontiersin.org
Primary immune regulatory disorders (PIRD) are associated with autoimmunity,
autoinflammation and/or dysregulation of lymphocyte homeostasis. Autoimmune …
autoinflammation and/or dysregulation of lymphocyte homeostasis. Autoimmune …
Hypomorphic caspase activation and recruitment domain 11 (CARD11) mutations associated with diverse immunologic phenotypes with or without atopic disease
B Dorjbal, JR Stinson, CA Ma, MA Weinreich… - Journal of Allergy and …, 2019 - Elsevier
Background Caspase activation and recruitment domain 11 (CARD11) encodes a scaffold
protein in lymphocytes that links antigen receptor engagement with downstream signaling to …
protein in lymphocytes that links antigen receptor engagement with downstream signaling to …
The CBM-opathies—a rapidly expanding spectrum of human inborn errors of immunity caused by mutations in the CARD11-BCL10-MALT1 complex
The caspase recruitment domain family member 11 (CARD11 or CARMA1)—B cell
CLL/lymphoma 10 (BCL10)—MALT1 paracaspase (MALT1)[CBM] signalosome complex …
CLL/lymphoma 10 (BCL10)—MALT1 paracaspase (MALT1)[CBM] signalosome complex …
Human inborn errors of immunity to herpes viruses
Infections with any of the nine human herpes viruses (HHV) can be asymptomatic or life-
threatening. The study of patients with severe diseases caused by HHVs, in the absence of …
threatening. The study of patients with severe diseases caused by HHVs, in the absence of …
Assembly mechanism of the CARMA1–BCL10–MALT1–TRAF6 signalosome
The CARMA1–BCL10–MALT1 (CBM) signalosome is a central mediator of T cell receptor
and B cell receptor-induced NF-κB signaling that regulates multiple lymphocyte functions …
and B cell receptor-induced NF-κB signaling that regulates multiple lymphocyte functions …
Hyper-IgE syndrome, 2021 update
Y Minegishi - Allergology International, 2021 - Elsevier
Clinically and pathologically, the patients with hyper-IgE syndrome present similar skin
manifestations to common atopic dermatitis. The original hyper-IgE syndrome is …
manifestations to common atopic dermatitis. The original hyper-IgE syndrome is …
Stratification of systemic lupus erythematosus patients into three groups of disease activity progression according to longitudinal gene expression
Objective The highly heterogeneous clinical presentation of systemic lupus erythematosus
(SLE) is characterized by the unpredictable occurrence of disease flares and organ damage …
(SLE) is characterized by the unpredictable occurrence of disease flares and organ damage …
Combined immunodeficiency and atopy caused by a dominant negative mutation in caspase activation and recruitment domain family member 11 (CARD11)
H Dadi, TA Jones, D Merico, N Sharfe, A Ovadia… - Journal of Allergy and …, 2018 - Elsevier
Background Combined immunodeficiency (CID) is a T-cell defect frequently presenting with
recurrent infections, as well as associated immune dysregulation manifesting as …
recurrent infections, as well as associated immune dysregulation manifesting as …