The AIDS epidemic has been a global public health issue for more than 40 years and has
resulted in~ 40 million deaths. AIDS is caused by the retrovirus, HIV-1, which is transmitted …

Successful approaches for eradication or cure of HIV-1 infection are likely to include
immunological mechanisms, but remarkably little is known about how human immune …

Human immunodeficiency virus (HIV) persistence in latently infected resting memory CD4+
T-cells is the major barrier to HIV cure. Cellular histone deacetylases (HDACs) are important …

To investigate whether the tumor suppressor gene PTEN affects the activity of the androgen
receptor (AR), we monitored the expression of the apoptotic gene HA-Bax (inserted in an …

The use of the polymerase chain reaction (PCR) in molecular diagnostics has increased to
the point where it is now accepted as the gold standard for detecting nucleic acids from a …

Background Quantifying latently infected cells is critical to evaluate the efficacy of
therapeutic strategies aimed at reducing the size of the long-lived viral reservoir, but the low …

The analysis of cytokine profiles helps to clarify functional properties of immune cells, both
for research and for clinical diagnosis. The real-time reverse transcription polymerase chain …

Use of PCR in the field of molecular diagnostics has increased to the point where it is now
accepted as the standard method for detecting nucleic acids from a number of sample and …

Objective: The protein kinase C (PKC) agonist bryostatin-1 has shown significant ex-vivo
potency to revert HIV-1 latency, compared with other latency reversing agents (LRA). The …

The source and dynamics of persistent HIV-1 during long-term combinational antiretroviral
therapy (cART) are critical to understanding the barriers to curing HIV-1 infection. To …