The endocannabinoid system and the brain
The psychoactive constituent in cannabis, Δ9-tetrahydrocannabinol (THC), was isolated in
the mid-1960s, but the cannabinoid receptors, CB1 and CB2, and the major endogenous …
the mid-1960s, but the cannabinoid receptors, CB1 and CB2, and the major endogenous …
Neurobiological interactions between stress and the endocannabinoid system
Stress affects a constellation of physiological systems in the body and evokes a rapid shift in
many neurobehavioral processes. A growing body of work indicates that the …
many neurobehavioral processes. A growing body of work indicates that the …
The endocannabinoid system in guarding against fear, anxiety and stress
The endocannabinoid (eCB) system has emerged as a central integrator linking the
perception of external and internal stimuli to distinct neurophysiological and behavioural …
perception of external and internal stimuli to distinct neurophysiological and behavioural …
The cannabinoid system and pain
Chronic pain states are highly prevalent and yet poorly controlled by currently available
analgesics, representing an enormous clinical, societal, and economic burden. Existing pain …
analgesics, representing an enormous clinical, societal, and economic burden. Existing pain …
A cannabinoid link between mitochondria and memory
Cellular activity in the brain depends on the high energetic support provided by
mitochondria, the cell organelles which use energy sources to generate ATP,,,. Acute …
mitochondria, the cell organelles which use energy sources to generate ATP,,,. Acute …
Enzyme inhibitor discovery by activity-based protein profiling
MJ Niphakis, BF Cravatt - Annual review of biochemistry, 2014 - annualreviews.org
Eukaryotic and prokaryotic organisms possess huge numbers of uncharacterized enzymes.
Selective inhibitors offer powerful probes for assigning functions to enzymes in native …
Selective inhibitors offer powerful probes for assigning functions to enzymes in native …
Integrating endocannabinoid signaling and cannabinoids into the biology and treatment of posttraumatic stress disorder
Exposure to stress is an undeniable, but in most cases surmountable, part of life. However,
in certain individuals, exposure to severe or cumulative stressors can lead to an array of …
in certain individuals, exposure to severe or cumulative stressors can lead to an array of …
Targeting the endocannabinoid system with cannabinoid receptor agonists: pharmacological strategies and therapeutic possibilities
RG Pertwee - … Transactions of the Royal Society B …, 2012 - royalsocietypublishing.org
Human tissues express cannabinoid CB1 and CB2 receptors that can be activated by
endogenously released 'endocannabinoids' or exogenously administered compounds in a …
endogenously released 'endocannabinoids' or exogenously administered compounds in a …
The endocannabinoid system as a target for novel anxiolytic drugs
The endocannabinoid (eCB) system has attracted attention for its role in various behavioral
and brain functions, and as a therapeutic target in neuropsychiatric disease states, including …
and brain functions, and as a therapeutic target in neuropsychiatric disease states, including …
[HTML][HTML] 2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain
Arachidonoylglycerol (2-AG) is a signaling lipid in the central nervous system that is a key
regulator of neurotransmitter release. 2-AG is an endocannabinoid that activates the …
regulator of neurotransmitter release. 2-AG is an endocannabinoid that activates the …