Chiral phosphorus ligands play a crucial role in asymmetric catalysis for the efficient
synthesis of useful optically active compounds. They are largely categorized into two …

Conspectus The use of quaternary stereocenters during lead candidate optimization
continues to grow because of improved physiochemical and pharmacokinetic profiles of …

Cross-electrophile coupling (XEC), defined by us as the cross-coupling of two different σ-
electrophiles that is driven by catalyst reduction, has seen rapid progression in recent years …

Conspectus The oxindole scaffold is a privileged structural motif that is found in a variety of
bioactive targets and natural products. Moreover, derivatives of the oxindole structure are …

A Ni-catalyzed enantioselective reductive diarylation of activated alkenes by domino
cyclizative/cross-coupling of two aryl bromides is developed. This reaction proceeds under …

The selective functionalization of ubiquitous but inert C–H bonds is highly appealing in
synthetic chemistry, but the direct transformation of hydrocarbons lacking directing groups …

Heck reaction is one of the most important carbon‐carbon bond forming reactions with wide
applications in organic synthesis. Considerable advances of enantioselective Heck reaction …

A nickel‐catalyzed asymmetric reductive Heck reaction of aryl chlorides has been
developed that affords substituted indolines with high enantioselectivity. Manganese powder …

A novel nickel-catalyzed cycloisomerization reaction forming a new carbon–carbon bond
while preserving the carbon–halogen bond has been developed. A cheap and readily …

Intramolecular carbometallation-initiated asymmetric transformations are a general and
powerful approach for the construction of carbo-and heterocyclic systems with one and more …