Secreted protein acidic and rich in cysteine (SPARC), also termed osteonectin or BM-40, is a
matricellular protein which regulates cell adhesion, extracellular matrix production, growth …

Humans exhibit a rich intestinal microbiome that contain high levels of bacteria capable of
producing 3-oxo-lithocholic acid (3-oxoLCA) and other secondary bile acids (BAs). The …

While numerous approaches have been reported towards understanding single cell
regulation, there is limited understanding of single cell production of extracellular matrix …

Extracellular matrix (ECM) alignment contributes to metastasis in a number of cancers and is
a known prognostic stromal factor; however, the mechanisms controlling matrix organization …

Background Paclitaxel/docetaxel after doxorubicin plus cyclophosphamide (ECT) is
considered as an adjuvant chemotherapy and improves the survival of early triple-negative …

Abstract Background MicroRNA (miRNA)-21-5p participates in various biological processes,
including cancer and autoimmune diseases. However, its role in the development of fibrosis …

Decades of research have concluded that disruptions to Phosphatase and tensin homolog
deleted on chromosome 10 (PTEN) have profound effects on cancer progression. However …

Simple Summary High mammographic density is a known risk factor for breast cancer.
However, the underlying mechanisms of high mammographic density development and …

Fibrosis is caused by pathological activation of resident fibroblasts to myofibroblasts that
leads to aberrant tissue stiffening and diminished function of affected organs with limited …

Aortic valve stenosis (AVS) is characterized by altered mechanics of the valve leaflets, which
disrupts blood flow through the aorta and can cause left ventricle hypotrophy. These …