Endogenous photosensitizers in human skin

EL Bastos, FH Quina, MS Baptista - Chemical Reviews, 2023 - ACS Publications
Endogenous photosensitizers play a critical role in both beneficial and harmful light-induced
transformations in biological systems. Understanding their mode of action is essential for …

Singlet molecular oxygen reactions with nucleic acids, lipids, and proteins

P Di Mascio, GR Martinez, S Miyamoto… - Chemical …, 2019 - ACS Publications
Singlet oxygen (1O2) is a biologically relevant reactive oxygen species capable of efficiently
reacting with cellular constituents. The resulting oxidatively generated damage to nucleic …

Intracellular delivery by membrane disruption: mechanisms, strategies, and concepts

MP Stewart, R Langer, KF Jensen - Chemical reviews, 2018 - ACS Publications
Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

Photodynamic therapy: past, present and future

U Chilakamarthi, L Giribabu - The Chemical Record, 2017 - Wiley Online Library
Though we crossed many milestones in the field of medicine and health care in eradicating
some deadly diseases over the past decades, cancer remained a challenge taking the lives …

Photodynamic efficiency: from molecular photochemistry to cell death

IOL Bacellar, TM Tsubone, C Pavani… - International journal of …, 2015 - mdpi.com
Photodynamic therapy (PDT) is a clinical modality used to treat cancer and infectious
diseases. The main agent is the photosensitizer (PS), which is excited by light and converted …

Giant vesicles: preparations and applications

P Walde, K Cosentino, H Engel, P Stano - ChemBioChem, 2010 - Wiley Online Library
There is considerable interest in preparing cell‐sized giant unilamellar vesicles from natural
or nonnatural amphiphiles because a giant vesicle membrane resembles the self‐closed …

Broad-spectrum antivirals against viral fusion

F Vigant, NC Santos, B Lee - Nature Reviews Microbiology, 2015 - nature.com
Effective antivirals have been developed against specific viruses, such as HIV, Hepatitis C
virus and influenza virus. This' one bug–one drug'approach to antiviral drug development …

Giant vesicles and their use in assays for assessing membrane phase state, curvature, mechanics, and electrical properties

R Dimova - Annual review of biophysics, 2019 - annualreviews.org
Giant unilamellar vesicles represent a promising and extremely useful model biomembrane
system for systematic measurements of mechanical, thermodynamic, electrical, and …

A comprehensive review on intracellular delivery

D Morshedi Rad, M Alsadat Rad… - Advanced …, 2021 - Wiley Online Library
Intracellular delivery is considered an indispensable process for various studies, ranging
from medical applications (cell‐based therapy) to fundamental (genome‐editing) and …

Low levels of lipid oxidation radically increase the passive permeability of lipid bilayers

KA Runas, N Malmstadt - Soft matter, 2015 - pubs.rsc.org
Oxidation of unsaturated lipids in cellular membranes has been shown to cause severe
membrane damage and potentially cell death. The presence of oxidized lipid species in the …