The fidelity of biological information flow is critical. Deoxyribonucleic acid (DNA) replication,
with its attendant proofreading and repair processes, has an error level in the range of 10-8 …

Mutations and rearrangements that occur by misalignment during DNA replication are
frequent sources of genetic variation in bacteria. Dislocations between a replicating strand …

Observed patterns of synonymous codon usage are explained in terms of the joint effects of
mutation, selection, and random drift. Examination of the codon usage in 165 Escherichia …

In terms of evolution and fitness, the most significant spontaneous mutation rate is likely to
be that for the entire genome (or its nonfrivolous fraction). Information is now available to …

A thermostable DNA polymerase which possesses an associated 3'-to-5'exonuclease
(proofreading) activity has been isolated from the hyperthermophilic archaebacterium …

Most algorithms for the alignment of biological sequences are not derived from an
evolutionary model. Consequently, these alignment algorithms lack a strong statistical basis …

8-Oxoguanine (8-oxo-7, 8-dihydroguanine) is produced in DNA, as well as in nucleotide
pools of cells, by active oxygen species normally formed during cellular metabolic …

The most common base substitution arising from oxidative damage of DNA is a GC→ AT
transition. In an effort to determine the oxidized lesion (s) that gives rise to this mutation, the …

The accuracy by which organisms duplicate their DNA is of considerable interest. At least
three mechanisms operate, serially, to secure high fidelity: base selection, exonucleolytic …

The DNA replication and transcription machineries share a common DNA template and thus
can collide with each other co-directionally or head-on,. Replication–transcription collisions …