The role of inflammation and infection in preterm birth

JA Bastek, LM Gómez… - Clinics in …, 2011 - perinatology.theclinics.com
Preterm birth is defined as delivery before 37 weeks' gestation. In 2010, the incidence of
preterm birth in the United States was 12.3% 1 and ranged from 8% to 12% in developed …

Amniotic fluid infection, inflammation, and colonization in preterm labor with intact membranes

CA Combs, M Gravett, TJ Garite, DE Hickok… - American journal of …, 2014 - Elsevier
Objective The purpose of this study was to compare intraamniotic inflammation vs microbial
invasion of the amniotic cavity (MIAC) as predictors of adverse outcome in preterm labor with …

The role of innate immune system in the human amniotic membrane and human amniotic fluid in protection against intra-amniotic infections and inflammation

T Šket, TŽ Ramuta, M Starčič Erjavec… - Frontiers in …, 2021 - frontiersin.org
Intra-amniotic infection and inflammation (IAI) affect fetal development and are highly
associated with preterm labor and premature rupture of membranes, which often lead to …

Midtrimester amniotic fluid concentrations of interleukin-6 and interferon-gamma-inducible protein-10: evidence for heterogeneity of intra-amniotic inflammation and …

MT Gervasi, R Romero, G Bracalente… - Journal of perinatal …, 2012 - degruyter.com
Introduction: Intra-amniotic inflammation is traditionally defined as an elevation of amniotic
fluid interleukin (IL)-6. Previous case control studies have suggested an association …

Adverse pregnancy and birth outcomes associated with Mycoplasma hominis, Ureaplasma urealyticum and Ureaplasma parvum: a systematic review and meta …

ME Jonduo, LM Vallely, H Wand, EL Sweeney… - BMJ open, 2022 - bmjopen.bmj.com
Objectives Mycoplasma hominis, Ureaplasma urealyticum and Ureaplasma parvum (genital
mycoplasmas) commonly colonise the urogenital tract in pregnant women. This systematic …

Synergic Activation of Toll-Like Receptor (TLR) 2/6 and 9 in Response to Ureaplasma parvum & urealyticum in Human Amniotic Epithelial Cells

M Triantafilou, B De Glanville, AF Aboklaish, OB Spiller… - PloS one, 2013 - journals.plos.org
Ureaplasma species are the most frequently isolated microorganisms inside the amniotic
cavity and have been associated with spontaneous abortion, chorioamnionitis, premature …

Abnormal uterine inflammation in obstetric syndromes: molecular insights into the role of chemokine decoy receptor D6 and inflammasome NLRP3

C Tersigni, M Vatish, S D'Ippolito… - Molecular Human …, 2020 - academic.oup.com
The adaptation of the uterine environment into a favorable immunological and inflammatory
milieu is a physiological process needed in normal pregnancy. A uterine hyperinflammatory …

The frequency and clinical significance of intra-amniotic inflammation in women with preterm uterine contractility but without cervical change: do the diagnostic criteria …

SM Kim, R Romero, JH Lee, S Mi Lee… - The Journal of …, 2012 - Taylor & Francis
Objective: The objective of this study was to determine the frequency and clinical
significance of intra-amniotic inflammation in patients with preterm increased uterine …

Diagnostic biomarkers of pro-inflammatory immune-mediated preterm birth

T Weissenbacher, RP Laubender, SS Witkin… - Archives of gynecology …, 2013 - Springer
Purpose Pro-inflammatory immunity, either infectious or sterile-derived, is one of the major
causes of preterm birth and associated with enhanced maternal and fetal morbidity and …

Human chorionic gonadotropin modulates CXCL10 expression through histone methylation in human decidua

M Silasi, Y You, S Simpson, J Kaislasuo, L Pal… - Scientific reports, 2020 - nature.com
The process of implantation, trophoblast invasion and placentation demand continuous
adaptation and modifications between the trophoblast (embryonic) and the decidua …