Clinical and biomedical applications of lensless holographic microscopy

CJ Potter, Z **ong, E McLeod - Laser & Photonics Reviews, 2024 - Wiley Online Library
Many clinical procedures and biomedical research workflows rely on microscopy, including
diagnosis of cancer, genetic disorders, autoimmune diseases, infections, and quantification …

Deep-learning-augmented computational miniature mesoscope

Y Xue, Q Yang, G Hu, K Guo, L Tian - Optica, 2022 - opg.optica.org
Fluorescence microscopy is essential to study biological structures and dynamics. However,
existing systems suffer from a trade-off between field of view (FOV), resolution, and system …

Mesoscopic calcium imaging in a head-unrestrained male non-human primate using a lensless microscope

J Wu, Y Chen, A Veeraraghavan, E Seidemann… - Nature …, 2024 - nature.com
Mesoscopic calcium imaging enables studies of cell-type specific neural activity over large
areas. A growing body of literature suggests that neural activity can be different when …

Design and single-shot fabrication of lensless cameras with arbitrary point spread functions

KC Lee, J Bae, N Baek, J Jung, W Park, SA Lee - Optica, 2023 - opg.optica.org
Lensless cameras are a novel class of computational imaging devices, in which the lenses
are replaced with a thin mask to achieve ultra-compact and low-cost hardware. In this paper …

Large depth-of-field ultra-compact microscope by progressive optimization and deep learning

Y Zhang, X Song, J **e, J Hu, J Chen, X Li… - Nature …, 2023 - nature.com
The optical microscope is customarily an instrument of substantial size and expense but
limited performance. Here we report an integrated microscope that achieves optical …

Ptychographic lens-less birefringence microscopy using a mask-modulated polarization image sensor

J Kim, S Song, H Kim, B Kim, M Park, SJ Oh, D Kim… - Scientific reports, 2023 - nature.com
Birefringence, an inherent characteristic of optically anisotropic materials, is widely utilized
in various imaging applications ranging from material characterizations to clinical diagnosis …

Direct laser writing-enabled 3D printing strategies for microfluidic applications

OM Young, X Xu, S Sarker, RD Sochol - Lab on a Chip, 2024 - pubs.rsc.org
Over the past decade, additive manufacturing—or “three-dimensional (3D) printing”—has
attracted increasing attention in the Lab on a Chip community as a pathway to achieve …

DeepDOF-SE: affordable deep-learning microscopy platform for slide-free histology

L **, Y Tang, JB Coole, MT Tan, X Zhao… - Nature …, 2024 - nature.com
Histopathology plays a critical role in the diagnosis and surgical management of cancer.
However, access to histopathology services, especially frozen section pathology during …

A subdural CMOS optical device for bidirectional neural interfacing

EH Pollmann, H Yin, I Uguz, A Dubey, KE Wingel… - Nature …, 2024 - nature.com
Optical neurotechnologies use light to interface with neurons and can monitor and
manipulate neural activity with high spatial-temporal precision over large cortical areas …

Real-time, deep-learning aided lensless microscope

J Wu, V Boominathan, A Veeraraghavan… - Biomedical Optics …, 2023 - opg.optica.org
Traditional miniaturized fluorescence microscopes are critical tools for modern biology.
Invariably, they struggle to simultaneously image with a high spatial resolution and a large …