Intracellular membrane traffic defines a complex network of pathways that connects many of
the membrane-bound organelles of eukaryotic cells. Although each pathway is governed by …

Membrane trafficking between organelles by vesiculotubular carriers is fundamental to the
existence of eukaryotic cells. Central in ensuring that cargoes are delivered to their correct …

Cytosolic lipid droplets (LDs) are the main storage organelles for metabolic energy in most
cells. They are unusual organelles that are bounded by a phospholipid monolayer and …

Intracellular membrane fusion is mediated in most cases by membrane-bridging complexes
of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) …

Bacteria and eukaryotic cells contain geometry-sensing tools in their cytosol: protein motifs
or domains that recognize the curvature, concave or convex, deep or shallow, of lipid …

Summary The Rab GTPases recruit peripheral membrane proteins to intracellular
organelles. These Rab effectors typically mediate the motility of organelles and vesicles and …

Lysosomes move bidirectionally on microtubules, and this motility can be stimulated by
overexpression of the small GTPase Arl8. By using affinity chromatography, we find that Arl8 …

Introduction The eukaryotic cell contains membrane-bound organelles with distinct
functionality and composition. Preservation of organelle identity depends on the highly …

The Golgi apparatus is a central intracellular membrane-bound organelle with key functions
in trafficking, processing, and sorting of newly synthesized membrane and secretory proteins …

Intracellular trafficking entails the budding, transport, tethering, and fusion of transport
vesicles and other membrane carriers. Here we review recent progress toward a …