Animal models play an indispensable role in the study of human diseases. However, animal
models of different diseases do not fully mimic the complex internal environment of humans …

The microbiome, the collection of microbial species at a site or compartment, has been an
underappreciated realm of human health up until the last decade. Mounting evidence …

Immune cells identify and destroy tumors by recognizing cellular traits indicative of
oncogenic transformation. In this study, we found that myocardin-related transcription factors …

Currently, most biological research relies on conventional experimental techniques that
allow only static analyses at certain time points in vitro or ex vivo. However, if one could …

HIV infection remains incurable to date and there are no compounds targeted at the viral
release. We show here HIV viral release is not spontaneous, rather requires caspases …

Plasma cells secreting affinity-matured antibodies develop in germinal centers (GCs), where
B cells migrate persistently and directionally over defined periods of time. How modes of GC …

Successful antiretroviral therapy (ART) can efficiently suppress Human Immunodeficiency
Virus-1 (HIV-1) replication to undetectable levels, but rare populations of infected memory …

T cells actively migrate along reticular networks within lymphoid organs in search for
cognate antigen, but how these behaviors impact HIV entry and infection is unclear. Here …

Trafficking of cell-associated HIV-1 from the genital mucosa to lymphoid organs represents a
critical first step toward systemic infection. Mature DCs capture and transmit HIV-1 to T cells …

Immature dendritic cells (iDCs) migrate in microenvironments with distinct cell and
extracellular matrix densities in vivo and contribute to HIV‐1 dissemination and mounting of …