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Guidelines for assessment of cardiac electrophysiology and arrhythmias in small animals
Cardiac arrhythmias are a major cause of morbidity and mortality worldwide. Although
recent advances in cell-based models, including human-induced pluripotent stem cell …
recent advances in cell-based models, including human-induced pluripotent stem cell …
Optical imaging of voltage and calcium in cardiac cells & tissues
Cardiac optical map** has proven to be a powerful technology for studying cardiovascular
function and disease. The development and scientific impact of this methodology are well …
function and disease. The development and scientific impact of this methodology are well …
Extracellular matrix–mediated maturation of human pluripotent stem cell–derived cardiac monolayer structure and electrophysiological function
Background—Human pluripotent stem cell–derived cardiomyocytes (hPSC-CMs)
monolayers generated to date display an immature embryonic-like functional and structural …
monolayers generated to date display an immature embryonic-like functional and structural …
Functional cardiac fibroblasts derived from human pluripotent stem cells via second heart field progenitors
Cardiac fibroblasts (CFs) play critical roles in heart development, homeostasis, and disease.
The limited availability of human CFs from native heart impedes investigations of CF biology …
The limited availability of human CFs from native heart impedes investigations of CF biology …
Electrotonic coupling of excitable and nonexcitable cells in the heart revealed by optogenetics
Electrophysiological studies of excitable organs usually focus on action potential (AP)-
generating cells, whereas nonexcitable cells are generally considered as barriers to …
generating cells, whereas nonexcitable cells are generally considered as barriers to …
Processing and analysis of cardiac optical map** data obtained with potentiometric dyes
Optical map** has become an increasingly important tool to study cardiac
electrophysiology in the past 20 years. Multiple methods are used to process and analyze …
electrophysiology in the past 20 years. Multiple methods are used to process and analyze …
Simultaneous voltage and calcium map** of genetically purified human induced pluripotent stem cell–derived cardiac myocyte monolayers
Rationale: Human induced pluripotent stem cell–derived cardiomyocytes (iPSC-CMs) offer a
powerful in vitro tool to investigate disease mechanisms and to perform patient-specific drug …
powerful in vitro tool to investigate disease mechanisms and to perform patient-specific drug …
Palette of fluorinated voltage-sensitive hemicyanine dyes
Optical recording of membrane potential permits spatially resolved measurement of
electrical activity in subcellular regions of single cells, which would be inaccessible to …
electrical activity in subcellular regions of single cells, which would be inaccessible to …
ESC working group on cardiac cellular electrophysiology position paper: relevance, opportunities, and limitations of experimental models for cardiac electrophysiology …
Cardiac arrhythmias are a major cause of death and disability. A large number of
experimental cell and animal models have been developed to study arrhythmogenic …
experimental cell and animal models have been developed to study arrhythmogenic …
A technical review of optical map** of intracellular calcium within myocardial tissue
Optical map** of Ca2+-sensitive fluorescence probes has become an extremely useful
approach and adopted by many cardiovascular research laboratories to study a spectrum of …
approach and adopted by many cardiovascular research laboratories to study a spectrum of …