Two centuries after the discovery of chitin, it is widely accepted that this biopolymer is an
important biomaterial in many aspects. Numerous studies on chitin have focused on its …

Understanding signaling and other complex biological processes requires elucidating the
critical roles of intrinsically disordered proteins (IDPs) and regions (IDRs), which represent∼ …

Transcriptional control requires epigenetic changes directed by mitochondrial tricarboxylic
acid (TCA) cycle metabolites. In the mouse embryo, global epigenetic changes occur during …

Functional analysis of the proteome is an essential part of genomic research. To facilitate
different proteomic approaches, a MORF (moveable ORF) library of 5854 yeast expression …

One of the prevailing hypotheses suggests schizophrenia as a neurodevelopmental
disorder, involving dysfunction of dopaminergic and glutamatergic systems. Accumulating …

The enzymes of O-GlcNAc cycling couple the nutrient-dependent synthesis of UDP-GlcNAc
to O-GlcNAc modification of Ser/Thr residues of key nuclear and cytoplasmic targets. This …

An increasing body of evidence points to a central regulatory role for glucose in mediating
cellular processes and expands the role of glucose well beyond its traditional role (s) in …

OBJECTIVE Carbohydrate-responsive element–binding protein (ChREBP) is a key
transcription factor that mediates the effects of glucose on glycolytic and lipogenic genes in …

The cluster of differentiation 36 (CD36) is a scavenger receptor present on various types of
cells and has multiple biological functions that may be important in inflammation and in the …

O-Linked GlcNAc modification of nuclear and cytosolic proteins has been shown to regulate
the function of many cellular proteins. Increased O-linked glycosylation, observed under …