Fibromyalgia: pathogenesis, mechanisms, diagnosis and treatment options update
Fibromyalgia is a syndrome characterized by chronic and widespread musculoskeletal pain,
often accompanied by other symptoms, such as fatigue, intestinal disorders and alterations …
often accompanied by other symptoms, such as fatigue, intestinal disorders and alterations …
[HTML][HTML] The anatomy of pain and suffering in the brain and its clinical implications
Pain is an unpleasant sensory and emotional experience associated with actual or potential
tissue damage. Chronic pain, with a prevalence of 20–30% is the major cause of human …
tissue damage. Chronic pain, with a prevalence of 20–30% is the major cause of human …
A somato-cognitive action network alternates with effector regions in motor cortex
Motor cortex (M1) has been thought to form a continuous somatotopic homunculus
extending down the precentral gyrus from foot to face representations,, despite evidence for …
extending down the precentral gyrus from foot to face representations,, despite evidence for …
First-in-human prediction of chronic pain state using intracranial neural biomarkers
Chronic pain syndromes are often refractory to treatment and cause substantial suffering
and disability. Pain severity is often measured through subjective report, while objective …
and disability. Pain severity is often measured through subjective report, while objective …
A distributed fMRI-based signature for the subjective experience of fear
The specific neural systems underlying the subjective feeling of fear are debated in affective
neuroscience. Here, we combine functional MRI with machine learning to identify and …
neuroscience. Here, we combine functional MRI with machine learning to identify and …
Brain–phenotype models fail for individuals who defy sample stereotypes
Individual differences in brain functional organization track a range of traits, symptoms and
behaviours,,,,,,,,,,–. So far, work modelling linear brain–phenotype relationships has …
behaviours,,,,,,,,,,–. So far, work modelling linear brain–phenotype relationships has …
Multivariate BWAS can be replicable with moderate sample sizes
Brain-wide association studies (BWAS)—which correlate individual differences in
phenotypic traits with measures of brain structure and function—have become a dominant …
phenotypic traits with measures of brain structure and function—have become a dominant …
Brain circuits for pain and its treatment
Pain is a multidimensional experience with sensory-discriminative, affective-motivational,
and cognitive-evaluative components. Pain aversiveness is one principal cause of suffering …
and cognitive-evaluative components. Pain aversiveness is one principal cause of suffering …
Placebo and nocebo effects
L Colloca, AJ Barsky - New England Journal of Medicine, 2020 - Mass Medical Soc
Placebo and Nocebo Effects Placebo and nocebo effects (effects of patients' positive and
negative expectations) are powerful and pervasive in clinical practice. Neurobiologic …
negative expectations) are powerful and pervasive in clinical practice. Neurobiologic …
Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities
Pain medication plays an important role in the treatment of acute and chronic pain
conditions, but some drugs, opioids in particular, have been overprescribed or prescribed …
conditions, but some drugs, opioids in particular, have been overprescribed or prescribed …