Brain metastases affect a significant percentage of patients with advanced extracranial
malignancies. Yet, the incidence of brain metastases remains poorly described, largely due …

This review integrates eight aspects of cerebrospinal fluid (CSF) circulatory dynamics:
formation rate, pressure, flow, volume, turnover rate, composition, recycling and …

Purpose The blood–brain barrier (BBB) essentially restricts therapeutic drugs from entering
into the brain. This study tests the hypothesis that brain endothelial cell derived exosomes …

Background Brain metastases are associated with significant morbidity and mortality.
Population-level data describing the incidence and prognosis of patients with brain …

Purpose: Brain metastases of breast cancer appear to be increasing in incidence, confer
significant morbidity, and threaten to compromise gains made in systemic chemotherapy …

Brain metastases are a serious obstacle in the treatment of patients with solid tumors and
contribute to the morbidity and mortality of these cancers. It is speculated that the frequency …

The delivery of many potentially therapeutic and diagnostic compounds to specific areas of
the brain is restricted by brain barriers, of which the most well known are the blood–brain …

Ligand-mediated drug delivery systems have enormous potential for improving the efficacy
of cancer treatment. In particular, Arg-Gly-Asp peptides are promising ligand molecules for …

Brain metastases occur commonly in patients with advanced solid malignancies. Yet, less is
known about brain metastases than cancer-related entities of similar incidence. Advances in …

The blood–brain barrier represents a significant challenge for the treatment of high-grade
gliomas, and our understanding of drug transport across this critical biointerface remains …