Photochemistry of flavoprotein light sensors

KS Conrad, CC Manahan, BR Crane - Nature chemical biology, 2014 - nature.com
Three major classes of flavin photosensors, light oxygen voltage (LOV) domains, blue light
sensor using FAD (BLUF) proteins and cryptochromes (CRYs), regulate diverse biological …

Optophysiology: Illuminating cell physiology with optogenetics

P Tan, L He, Y Huang, Y Zhou - Physiological reviews, 2022 - journals.physiology.org
Optogenetics combines light and genetics to enable precise control of living cells, tissues,
and organisms with tailored functions. Optogenetics has the advantages of …

Hydrocarbon synthesis via photoenzymatic decarboxylation of carboxylic acids

W Zhang, M Ma, MME Huijbers… - Journal of the …, 2019 - ACS Publications
A recently discovered photodecarboxylase from Chlorella variabilis NC64A (Cv FAP) bears
the promise for the efficient and selective synthesis of hydrocarbons from carboxylic acids …

Spectroscopic and computational observation of glutamine tautomerization in the blue light sensing using flavin domain photoreaction

Y Hontani, J Mehlhorn, T Domratcheva… - Journal of the …, 2023 - ACS Publications
Blue light sensing using flavin (BLUF) domains constitute a family of flavin-binding
photoreceptors of bacteria and eukaryotic algae. BLUF photoactivation proceeds via a light …

Unraveling the photoactivation mechanism of a light-activated adenylyl cyclase using ultrafast spectroscopy coupled with unnatural amino acid mutagenesis

J Tolentino Collado, JN Iuliano, K Pirisi… - ACS chemical …, 2022 - ACS Publications
The hydrogen bonding network that surrounds the flavin in blue light using flavin adenine
dinucleotide (BLUF) photoreceptors plays a crucial role in sensing and communicating the …

Optobiochemistry: genetically encoded control of protein activity by light

J Seong, MZ Lin - Annual Review of Biochemistry, 2021 - annualreviews.org
Optobiochemical control of protein activities allows the investigation of protein functions in
living cells with high spatiotemporal resolution. Over the last two decades, numerous natural …

The nature of proton-coupled electron transfer in a blue light using flavin domain

Z Zhou, Z Chen, XW Kang, Y Zhou… - Proceedings of the …, 2022 - National Acad Sciences
Proton-coupled electron transfer (PCET) is key to the activation of the blue light using flavin
(BLUF) domain photoreceptors. Here, to elucidate the photocycle of the central FMN-Gln-Tyr …

Light-induced chromophore and protein responses and mechanical signal transduction of BLUF proteins

T Fujisawa, S Masuda - Biophysical reviews, 2018 - Springer
Photoreceptor proteins have been used to study how protein conformational changes are
induced by alterations in their environments and how their signals are transmitted to …

Constructing molecular π-orbital active spaces for multireference calculations of conjugated systems

ER Sayfutyarova… - Journal of chemical theory …, 2019 - ACS Publications
Molecules with conjugated π systems often feature strong electron correlation and therefore
require multireference methods for a reliable computational description. A key prerequisite …

Early photocycle of Slr1694 blue-light using flavin photoreceptor unraveled through adiabatic excited-state quantum mechanical/molecular mechanical dynamics

JJ Goings, S Hammes-Schiffer - Journal of the American Chemical …, 2019 - ACS Publications
Blue-light using flavin (BLUF) photoreceptor proteins are essential to many biological
processes and are attractive candidates for use in optogenetics. To understand the …