G-quadruplex DNA targeted metal complexes acting as potential anticancer drugs
Although cisplatin and its analogues have been widely utilized as anticancer metallodrugs
in clinics, their serious side effects and damage to normal tissues cannot be avoided …
in clinics, their serious side effects and damage to normal tissues cannot be avoided …
Cytotoxic platinum coordination compounds. DNA binding agents
V Brabec, O Hrabina, J Kasparkova - Coordination Chemistry Reviews, 2017 - Elsevier
Despite the widespread use of antineoplastic platinum drugs, a number of accompanying
disadvantages exist. In connection with attempts to circumvent these problems new platinum …
disadvantages exist. In connection with attempts to circumvent these problems new platinum …
Platinum (II)‐Based Optical Probes for Imaging Quadruplex DNA Structures via Phosphorescence Lifetime Imaging Microscopy
G‐quadruplex DNA is a non‐canonical structure that forms in guanine‐rich regions of the
genome. There is increasing evidence showing that G‐quadruplexes have important …
genome. There is increasing evidence showing that G‐quadruplexes have important …
On the Mechanism of Gold/NHC Compounds Binding to DNA G‐Quadruplexes: Combined Metadynamics and Biophysical Methods
The binding modes and free‐energy landscape of two AuI/N‐heterocyclic carbene
complexes interacting with G‐quadruplexes, namely a human telomeric (hTelo) and a …
complexes interacting with G‐quadruplexes, namely a human telomeric (hTelo) and a …
Towards the Development of Photo‐Reactive Ruthenium (II) Complexes Targeting Telomeric G‐Quadruplex DNA
The design and characterization of new ruthenium (II) complexes aimed at targeting G‐
quadruplex DNA is reported. Importantly, these complexes are based on oxidizing 1, 4, 5, 8 …
quadruplex DNA is reported. Importantly, these complexes are based on oxidizing 1, 4, 5, 8 …
Structural Studies Reveal Enantiospecific Recognition of a DNA G‐Quadruplex by a Ruthenium Polypyridyl Complex
K McQuaid, H Abell, SP Gurung… - Angewandte Chemie …, 2019 - Wiley Online Library
By using X‐ray crystallography, we show that the complexes Λ/Δ‐[Ru (TAP) 2 (11‐CN‐
dppz)] 2+(TAP= 1, 4, 5, 8‐tetraazaphenanthrene, dppz= dipyridophenazine) bind DNA G …
dppz)] 2+(TAP= 1, 4, 5, 8‐tetraazaphenanthrene, dppz= dipyridophenazine) bind DNA G …
Platinum intercalators of DNA as anticancer agents
BJ Pages, KB Garbutcheon‐Singh… - European Journal of …, 2017 - Wiley Online Library
The drawbacks of the platinum chemotherapy agents cisplatin, carboplatin and oxaliplatin
have inspired the development of compounds with different mechanisms of action …
have inspired the development of compounds with different mechanisms of action …
Synthesis and anticancer mechanisms of four novel platinum (ii) 4′-substituted-2, 2′: 6′, 2′′-terpyridine complexes
CJ Liang, RC Wu, XQ Huang, QP Qin, H Liang… - Dalton …, 2024 - pubs.rsc.org
Mitophagy, a selective autophagic process, has emerged as a pathway involved in
degrading dysfunctional mitochondria. Herein, new platinum (II)-based chemotherapeutics …
degrading dysfunctional mitochondria. Herein, new platinum (II)-based chemotherapeutics …
Novel planar Pt (ii) cyclometallated cytotoxic complexes with g-quadruplex stabilisation and luminescent properties
Herein is described the development of a series of novel quadruplex DNA (QDNA)-
stabilising cyclometallated square–planar metal complexes (CMCs). Melting experiments …
stabilising cyclometallated square–planar metal complexes (CMCs). Melting experiments …
The interaction of Schiff Base complexes of nickel (II) and zinc (II) with duplex and G-quadruplex DNA
The duplex and G-quadruplex DNA-binding of six nickel (II) and zinc (II) complexes of three
salphen-like ligands (salphen= N, N′-bis-salicylidene-1, 2-phenylenediaminato) was …
salphen-like ligands (salphen= N, N′-bis-salicylidene-1, 2-phenylenediaminato) was …