Hallmarks of response, resistance, and toxicity to immune checkpoint blockade
G Morad, BA Helmink, P Sharma, JA Wargo - Cell, 2021 - cell.com
Unprecedented advances have been made in cancer treatment with the use of immune
checkpoint blockade (ICB). However, responses are limited to a subset of patients, and …
checkpoint blockade (ICB). However, responses are limited to a subset of patients, and …
Tumor-infiltrating lymphocytes in the immunotherapy era
ST Paijens, A Vledder, M de Bruyn… - Cellular & molecular …, 2021 - nature.com
The clinical success of cancer immune checkpoint blockade (ICB) has refocused attention
on tumor-infiltrating lymphocytes (TILs) across cancer types. The outcome of immune …
on tumor-infiltrating lymphocytes (TILs) across cancer types. The outcome of immune …
[PDF][PDF] Breast Cancer: Updated and Deep Insights
Breast cancer is the most common cancer diagnosed in females throughout the entire world,
and it is also the primary reason why people lose their lives due to malignant tumors. The …
and it is also the primary reason why people lose their lives due to malignant tumors. The …
Benchmarking of cell type deconvolution pipelines for transcriptomics data
Many computational methods have been developed to infer cell type proportions from bulk
transcriptomics data. However, an evaluation of the impact of data transformation, pre …
transcriptomics data. However, an evaluation of the impact of data transformation, pre …
Nanocatalyst‐mediated chemodynamic tumor therapy
L Zhang, CX Li, SS Wan… - Advanced healthcare …, 2022 - Wiley Online Library
Traditional tumor treatments, including chemotherapy, radiotherapy, photodynamic therapy,
and photothermal therapy, are developed and used to treat different types of cancer …
and photothermal therapy, are developed and used to treat different types of cancer …
Tumor-infiltrating lymphocytes and their prognostic value in cutaneous melanoma
F Maibach, H Sadozai, SM Seyed Jafari… - Frontiers in …, 2020 - frontiersin.org
Recent breakthroughs in tumor immunotherapy such as immune checkpoint blockade (ICB)
antibodies, have demonstrated the capacity of the immune system to fight cancer in a …
antibodies, have demonstrated the capacity of the immune system to fight cancer in a …
Artificial intelligence as the next step towards precision pathology
Pathology is the cornerstone of cancer care. The need for accuracy in histopathologic
diagnosis of cancer is increasing as personalized cancer therapy requires accurate …
diagnosis of cancer is increasing as personalized cancer therapy requires accurate …
[HTML][HTML] Spatial organization and molecular correlation of tumor-infiltrating lymphocytes using deep learning on pathology images
Beyond sample curation and basic pathologic characterization, the digitized H&E-stained
images of TCGA samples remain underutilized. To highlight this resource, we present …
images of TCGA samples remain underutilized. To highlight this resource, we present …
An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte–tumor cell crosstalk, local immunosuppression and tumor progression
Dissecting and understanding the cancer ecosystem, especially that around the tumor
margins, which have strong implications for tumor cell infiltration and invasion, are essential …
margins, which have strong implications for tumor cell infiltration and invasion, are essential …
Pembrolizumab plus trastuzumab in trastuzumab-resistant, advanced, HER2-positive breast cancer (PANACEA): a single-arm, multicentre, phase 1b–2 trial
Background HER2-positive breast cancers usually contain large amounts of T-cell infiltrate.
We hypothesised that trastuzumab resistance in HER2-positive breast cancer could be …
We hypothesised that trastuzumab resistance in HER2-positive breast cancer could be …