Unprecedented advances have been made in cancer treatment with the use of immune
checkpoint blockade (ICB). However, responses are limited to a subset of patients, and …

Abstract The “hotness” or “coldness” of the tumors are determined by the information of the
cancer cells themselves, tumor immune characteristics, tumor microenvironment, and …

Dissecting and understanding the cancer ecosystem, especially that around the tumor
margins, which have strong implications for tumor cell infiltration and invasion, are essential …

The clinical success of cancer immune checkpoint blockade (ICB) has refocused attention
on tumor-infiltrating lymphocytes (TILs) across cancer types. The outcome of immune …

Many computational methods have been developed to infer cell type proportions from bulk
transcriptomics data. However, an evaluation of the impact of data transformation, pre …

Pathology is the cornerstone of cancer care. The need for accuracy in histopathologic
diagnosis of cancer is increasing as personalized cancer therapy requires accurate …

Breast cancer is the most common cancer diagnosed in females throughout the entire world,
and it is also the primary reason why people lose their lives due to malignant tumors. The …

Beyond sample curation and basic pathologic characterization, the digitized H&E-stained
images of TCGA samples remain underutilized. To highlight this resource, we present …

Traditional tumor treatments, including chemotherapy, radiotherapy, photodynamic therapy,
and photothermal therapy, are developed and used to treat different types of cancer …

In 2014, we described a method to quantify percentage of tumor-infiltrating lymphocytes
(TILs) on hematoxylin and eosin-stained slides of breast cancer samples using light …