Privileged structures have been widely used as an effective template for the research and
discovery of high value chemicals. Coumarin is a simple scaffold widespread in Nature and …

Although anticoagulants have been in use for more than 80 years, heparin and vitamin K
antagonists were the sole available options until recently. Although these agents …

This guidance document was prepared on behalf of the International Council for
Standardization in Haematology (ICSH) for providing haemostasis-related guidance …

In 2018, the International Council for Standardization in Haematology (ICSH) published a
consensus document providing guidance for laboratories on measuring direct oral …

Venous thromboembolism (VTE) refers to deep vein thrombosis (DVT), whose consequence
may be a pulmonary embolism (PE). Thrombosis is associated with significant morbidity and …

Background Lupus anticoagulants (LA) are one laboratory criterion for classification of
antiphospholipid syndrome, with presence of vascular thrombosis and/or pregnancy/fetal …

Thrombosis, which seriously endangers human health and life, is the leading cause of
morbidity and mortality globally. Antithrombotic drugs can interfere with the occurrence and …

Coumarins constitute a relatively new class of inhibitors of the zinc enzyme carbonic
anhydrase (CA, EC 4.2. 1.1), possessing a unique inhibition mechanism, acting as “prodrug …

Isocoumarins, isomeric to comarins which act as effective carbonic anhydrase (CA, EC 4.2.
1.1) inhibitors, were investigated for the first time as inhibitors of this enzyme. A series of 3 …

Apixaban, a direct oral anticoagulant, has emerged over the past few years because it is
considered to have a low risk of drug‐drug interactions compared to vitamin K antagonists …