Chronic obstructive pulmonary disease exacerbation fundamentals: diagnosis, treatment, prevention and disease impact

M MacLeod, A Papi, M Contoli, B Beghé, BR Celli… - …, 2021 - Wiley Online Library
In chronic obstructive pulmonary disease (COPD), exacerbations (ECOPD), characterized
by an acute deterioration in respiratory symptoms, are fundamental events impacting …

The airway epithelium: soldier in the fight against respiratory viruses

M Vareille, E Kieninger, MR Edwards… - Clinical microbiology …, 2011 - journals.asm.org
The airway epithelium acts as a frontline defense against respiratory viruses, not only as a
physical barrier and through the mucociliary apparatus but also through its immunological …

Host–microorganism interactions in lung diseases

BJ Marsland, ES Gollwitzer - Nature Reviews Immunology, 2014 - nature.com
Until recently, the airways were thought to be sterile unless infected; however, a shift
towards molecular methods for the quantification and sequencing of bacterial DNA has …

Air pollution and respiratory viral infection

J Ciencewicki, I Jaspers - Inhalation toxicology, 2007 - Taylor & Francis
Despite current regulations, which limit the levels of certain air pollutants, there are still a
number of adverse health effects that result from exposure to these agents. Numerous …

Long-term effects of inhaled corticosteroids on sputum bacterial and viral loads in COPD

M Contoli, A Pauletti, MR Rossi… - European …, 2017 - publications.ersnet.org
Inhaled corticosteroid-containing medications reduce the frequency of COPD exacerbations
(mainly infectious in origin) while paradoxically increasing the risk of other respiratory …

Selective inhibitors of picornavirus replication

AM De Palma, I Vliegen, E De Clercq… - Medicinal research …, 2008 - Wiley Online Library
Picornaviruses cover a large family of pathogens that have a major impact on human but
also on veterinary health. Although most infections in man subside mildly or …

[HTML][HTML] Secretory immunoglobulin a immunity in chronic obstructive respiratory diseases

C de Fays, FM Carlier, S Gohy, C Pilette - Cells, 2022 - mdpi.com
Chronic obstructive pulmonary disease (COPD), asthma and cystic fibrosis (CF) are distinct
respiratory diseases that share features such as the obstruction of small airways and …

Cigarette smoke selectively enhances viral PAMP–and virus-induced pulmonary innate immune and remodeling responses in mice

MJ Kang, CG Lee, JY Lee, CSD Cruz, ZJ Chen… - The Journal of clinical …, 2008 - jci.org
Viral infections have more severe consequences in patients who have been exposed to
cigarette smoke (CS) than in those not exposed to CS. For example, in chronic obstructive …

Combating enterovirus replication: state-of-the-art on antiviral research

HJ Thibaut, AM De Palma, J Neyts - Biochemical pharmacology, 2012 - Elsevier
Enteroviruses form an important genus within the large family of Picornaviridae. They are
small, non-enveloped (+) RNA viruses, many of which are important pathogens in human …

[HTML][HTML] Unique synergistic antiviral effects of Shufeng Jiedu Capsule and oseltamivir in influenza A viral-induced acute exacerbation of chronic obstructive pulmonary …

S Ji, Q Bai, X Wu, DW Zhang, S Wang, JL Shen… - Biomedicine & …, 2020 - Elsevier
Background The aim of the present study was to investigate the synergistic effects and
interactive mechanisms of Shufeng Jiedu Capsule (SFJDC) combined with oseltamivir in the …