The physiology, pathology, and pharmacology of voltage-gated calcium channels and their future therapeutic potential

GW Zamponi, J Striessnig, A Koschak… - Pharmacological …, 2015 - Elsevier
Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …

Voltage-gated calcium channels

WA Catterall - Cold Spring Harbor perspectives in …, 2011 - cshperspectives.cshlp.org
Voltage-gated calcium (Ca2+) channels are key transducers of membrane potential
changes into intracellular Ca2+ transients that initiate many physiological events. There are …

Structure and Regulation of Voltage-Gated Ca2+ Channels

WA Catterall - Annual review of cell and developmental biology, 2000 - annualreviews.org
▪ Abstract Voltage-gated Ca2+ channels mediate Ca2+ entry into cells in response to
membrane depolarization. Electrophysiological studies reveal different Ca2+ currents …

The scanning model for translation: an update.

M Kozak - The Journal of cell biology, 1989 - rupress.org
The small (40S) subunit of eukaryotic ribosomes is believed to bind initially at the capped 5'-
end of messenger RNA and then migrate, stop** at the first AUG codon in a favorable …

[BOOK][B] Excitation-contraction coupling and cardiac contractile force

D Bers - 2001 - books.google.com
How is the heartbeat generated? What controls the strength of contraction of heart muscle?
What are the links between cardiac structure and function? How does our understanding of …

Molecular physiology of cardiac repolarization

JM Nerbonne, RS Kass - Physiological reviews, 2005 - journals.physiology.org
The heart is a rhythmic electromechanical pump, the functioning of which depends on action
potential generation and propagation, followed by relaxation and a period of refractoriness …

Presynaptic calcium channels: specialized control of synaptic neurotransmitter release

AC Dolphin, A Lee - Nature Reviews Neuroscience, 2020 - nature.com
Chemical synapses are heterogeneous junctions formed between neurons that are
specialized for the conversion of electrical impulses into the exocytotic release of …

The Novel Anticonvulsant Drug, Gabapentin (Neurontin), Binds to the α2δ Subunit of a Calcium Channel (∗)

NS Gee, JP Brown, VUK Dissanayake, J Offord… - Journal of Biological …, 1996 - jbc.org
Gabapentin (1-(aminomethyl) cyclohexane acetic acid; Neurontin) is a novel anticonvulsant
drug, with a mechanism of action apparently dissimilar to that of other antiepileptic agents …

Voltage‐gated calcium channels and their auxiliary subunits: physiology and pathophysiology and pharmacology

AC Dolphin - The Journal of physiology, 2016 - Wiley Online Library
Voltage‐gated calcium channels are essential players in many physiological processes in
excitable cells. There are three main subdivisions of calcium channel, defined by the pore …

Primary structure and expression from complementary DNA of skeletal muscle ryanodine receptor

H Takeshima, S Nishimura, T Matsumoto, H Ishida… - Nature, 1989 - nature.com
The sequence of 5,037 amino acids composing the ryanodine receptor from rabbit skeletal
muscle sarcoplasmic reticulum has been deduced by cloning and sequencing the …