Gene regulatory network inference resources: A practical overview
Transcriptional regulation is a fundamental molecular mechanism involved in almost every
aspect of life, from homeostasis to development, from metabolism to behavior, from reaction …
aspect of life, from homeostasis to development, from metabolism to behavior, from reaction …
Unraveling the structure and biological functions of RNA triple helices
JA Brown - Wiley Interdisciplinary Reviews: RNA, 2020 - Wiley Online Library
It has been nearly 63 years since the first characterization of an RNA triple helix in vitro by
Gary Felsenfeld, David Davies, and Alexander Rich. An RNA triple helix consists of three …
Gary Felsenfeld, David Davies, and Alexander Rich. An RNA triple helix consists of three …
Human DNA topoisomerase I poisoning causes R loop–mediated genome instability attenuated by transcription factor IIS
DNA topoisomerase I can contribute to cancer genome instability. During catalytic activity,
topoisomerase I forms a transient intermediate, topoisomerase I–DNA cleavage complex …
topoisomerase I forms a transient intermediate, topoisomerase I–DNA cleavage complex …
R-Loop Tracker: Web Access-Based Tool for R-Loop Detection and Analysis in Genomic DNA Sequences
R-loops are common non-B nucleic acid structures formed by a three-stranded nucleic acid
composed of an RNA–DNA hybrid and a displaced single-stranded DNA (ssDNA) loop …
composed of an RNA–DNA hybrid and a displaced single-stranded DNA (ssDNA) loop …
Approaches for Map** and Analysis of R‐loops
R‐loops are nucleic acid structures composed of a DNA: RNA hybrid with a displaced non‐
template single‐stranded DNA. Current approaches to identify and map R‐loop formation …
template single‐stranded DNA. Current approaches to identify and map R‐loop formation …
[HTML][HTML] RLSuite: An integrative R-loop bioinformatics framework
We recently described the development of a database of 810 R-loop map** datasets and
used this data to conduct a meta-analysis of R-loops. R-loops are three-stranded nucleic …
used this data to conduct a meta-analysis of R-loops. R-loops are three-stranded nucleic …
Seq'ing identity and function in a repeat-derived noncoding RNA world
RJ O'Neill - Chromosome Research, 2020 - Springer
Innovations in high-throughout sequencing approaches are being marshaled to both reveal
the composition of the abundant and heterogeneous noncoding RNAs that populate cell …
the composition of the abundant and heterogeneous noncoding RNAs that populate cell …
Unbalanced R-loops and micronuclei induced by DNA topoisomerase I poisons in cancer cells
RC Duardo - 2022 - amsdottorato.unibo.it
Topoisomerase I (Top1) poisons are among the most clinically-effective drugs used for
colon, ovary and lung cancers. Unpublished data from our lab have recently revealed that …
colon, ovary and lung cancers. Unpublished data from our lab have recently revealed that …
Multiomic characterization of the effects of G-quadruplex binders on R-loop homeostasis and innate immune response in human cancer cells
M Russo - 2020 - amsdottorato.unibo.it
R-loops are non-canonical DNA structures consisting of a DNA-RNA hybrid and a displaced
ssDNA. R-loops can be structurally compatible with G-quadruplexes, that are secondary …
ssDNA. R-loops can be structurally compatible with G-quadruplexes, that are secondary …