Tumor heterogeneity reshapes the tumor microenvironment to influence drug resistance

A Zhang, K Miao, H Sun… - International journal of …, 2022 - pmc.ncbi.nlm.nih.gov
Tumor heterogeneity is one of the hallmarks of cancer and a challenge in the field of
oncology. Tumor heterogeneity is the main cause of drug resistance, leading to therapeutic …

T cell-engaging therapies—BiTEs and beyond

ME Goebeler, RC Bargou - Nature Reviews Clinical Oncology, 2020 - nature.com
Immuno-oncology approaches have entered clinical practice, with tremendous progress
particularly in the field of T cell-engaging therapies over the past decade. Herein, we provide …

Cell-free DNA analysis in current cancer clinical trials: a review

M Cisneros-Villanueva, L Hidalgo-Pérez… - British journal of …, 2022 - nature.com
Cell-free DNA (cfDNA) analysis represents a promising method for the diagnosis, treatment
selection and clinical follow-up of cancer patients. Although its general methodological …

Liquid biopsy: Exosomal microRNAs as novel diagnostic and prognostic biomarkers in cancer

KA Preethi, SC Selvakumar, K Ross, S Jayaraman… - Molecular Cancer, 2022 - Springer
Background Detecting cancer at an early stage before clinical manifestation could be an
effective strategy to decrease cancer mortality. Thus, identifying liquid biopsy biomarkers …

Shifting the cancer screening paradigm: the rising potential of blood-based multi-cancer early detection tests

T Brito-Rocha, V Constâncio, R Henrique, C Jerónimo - Cells, 2023 - mdpi.com
Cancer remains a leading cause of death worldwide, partly owing to late detection which
entails limited and often ineffective therapeutic options. Most cancers lack validated …

Liquid biopsies: applications for cancer diagnosis and monitoring

I Martins, IP Ribeiro, J Jorge, AC Gonçalves… - Genes, 2021 - mdpi.com
The minimally—or non-invasive detection of circulating tumor-derived components in
biofluids, such as blood, liquid biopsy is a revolutionary approach with significant potential …

Role of ensemble deep learning for brain tumor classification in multiple magnetic resonance imaging sequence data

GS Tandel, A Tiwari, OG Kakde, N Gupta, L Saba… - Diagnostics, 2023 - mdpi.com
The biopsy is a gold standard method for tumor grading. However, due to its invasive nature,
it has sometimes proved fatal for brain tumor patients. As a result, a non-invasive computer …

Circulating tumor cells: from new biological insights to clinical practice

X Gu, S Wei, X Lv - Signal transduction and targeted therapy, 2024 - nature.com
The primary reason for high mortality rates among cancer patients is metastasis, where
tumor cells migrate through the bloodstream from the original site to other parts of the body …

[HTML][HTML] DNA methylation-based testing in liquid biopsies as detection and prognostic biomarkers for the four major cancer types

V Constâncio, SP Nunes, R Henrique, C Jerónimo - Cells, 2020 - mdpi.com
Lung, breast, colorectal, and prostate cancers are the most incident worldwide. Optimal
population-based cancer screening methods remain an unmet need, since cancer detection …

CRISPR/Cas9 and next generation sequencing in the personalized treatment of Cancer

SC Selvakumar, KA Preethi, K Ross, D Tusubira… - Molecular Cancer, 2022 - Springer
Background Cancer is caused by a combination of genetic and epigenetic abnormalities.
Current cancer therapies are limited due to the complexity of their mechanism, underlining …