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Tumor heterogeneity reshapes the tumor microenvironment to influence drug resistance
Tumor heterogeneity is one of the hallmarks of cancer and a challenge in the field of
oncology. Tumor heterogeneity is the main cause of drug resistance, leading to therapeutic …
oncology. Tumor heterogeneity is the main cause of drug resistance, leading to therapeutic …
T cell-engaging therapies—BiTEs and beyond
ME Goebeler, RC Bargou - Nature Reviews Clinical Oncology, 2020 - nature.com
Immuno-oncology approaches have entered clinical practice, with tremendous progress
particularly in the field of T cell-engaging therapies over the past decade. Herein, we provide …
particularly in the field of T cell-engaging therapies over the past decade. Herein, we provide …
Cell-free DNA analysis in current cancer clinical trials: a review
M Cisneros-Villanueva, L Hidalgo-Pérez… - British journal of …, 2022 - nature.com
Cell-free DNA (cfDNA) analysis represents a promising method for the diagnosis, treatment
selection and clinical follow-up of cancer patients. Although its general methodological …
selection and clinical follow-up of cancer patients. Although its general methodological …
Liquid biopsy: Exosomal microRNAs as novel diagnostic and prognostic biomarkers in cancer
Background Detecting cancer at an early stage before clinical manifestation could be an
effective strategy to decrease cancer mortality. Thus, identifying liquid biopsy biomarkers …
effective strategy to decrease cancer mortality. Thus, identifying liquid biopsy biomarkers …
Shifting the cancer screening paradigm: the rising potential of blood-based multi-cancer early detection tests
Cancer remains a leading cause of death worldwide, partly owing to late detection which
entails limited and often ineffective therapeutic options. Most cancers lack validated …
entails limited and often ineffective therapeutic options. Most cancers lack validated …
Liquid biopsies: applications for cancer diagnosis and monitoring
The minimally—or non-invasive detection of circulating tumor-derived components in
biofluids, such as blood, liquid biopsy is a revolutionary approach with significant potential …
biofluids, such as blood, liquid biopsy is a revolutionary approach with significant potential …
Role of ensemble deep learning for brain tumor classification in multiple magnetic resonance imaging sequence data
The biopsy is a gold standard method for tumor grading. However, due to its invasive nature,
it has sometimes proved fatal for brain tumor patients. As a result, a non-invasive computer …
it has sometimes proved fatal for brain tumor patients. As a result, a non-invasive computer …
Circulating tumor cells: from new biological insights to clinical practice
X Gu, S Wei, X Lv - Signal transduction and targeted therapy, 2024 - nature.com
The primary reason for high mortality rates among cancer patients is metastasis, where
tumor cells migrate through the bloodstream from the original site to other parts of the body …
tumor cells migrate through the bloodstream from the original site to other parts of the body …
[HTML][HTML] DNA methylation-based testing in liquid biopsies as detection and prognostic biomarkers for the four major cancer types
Lung, breast, colorectal, and prostate cancers are the most incident worldwide. Optimal
population-based cancer screening methods remain an unmet need, since cancer detection …
population-based cancer screening methods remain an unmet need, since cancer detection …
CRISPR/Cas9 and next generation sequencing in the personalized treatment of Cancer
Background Cancer is caused by a combination of genetic and epigenetic abnormalities.
Current cancer therapies are limited due to the complexity of their mechanism, underlining …
Current cancer therapies are limited due to the complexity of their mechanism, underlining …