Atherosclerosis is one type of cardiovascular disease (CVD) in which activation of the
NLRP3 inflammasome and toll-like receptor (TLR) pathways is implicated. One of the most …

Hydroxy-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors or statins are well
tolerated, but associated with various statin-associated symptoms (SAS), including statin …

Statins are lipid-lowering therapeutics with favorable anti-inflammatory profiles and have
been proposed as an adjunct therapy for COVID-19. However, statins may increase the risk …

The production of various reactive oxidant species in excess of endogenous antioxidant
defense mechanisms promotes the development of a state of oxidative stress, with …

Inflammasomes are protein complexes formed upon encounter of microbial or damage-
associated stimuli. The main output of inflammasome assembly is activation of caspase-1, a …

Rationale: The relationship between the development and/or progression of interstitial lung
abnormalities (ILA) and clinical outcomes has not been previously investigated. Objectives …

Rationale: Interstitial lung abnormalities (ILA) are radiologic abnormalities on chest
computed tomography scans that have been associated with an early or mild form of …

Background A common promoter polymorphism (rs35705950) in MUC5B, the gene
encoding mucin 5B, is associated with idiopathic pulmonary fibrosis. It is not known whether …

Intermediates in the cholesterol-biosynthetic pathway and oxysterol derivatives of
cholesterol regulate diverse cellular processes. Recent studies have expanded the …

Acute respiratory distress syndrome (ARDS) is a severe clinical disorder characterized by its
acute onset, diffuse alveolar damage, intractable hypoxemia, and non-cardiogenic …