Terminology, molecular features, epidemiology, and management of serrated colorectal neoplasia
In addition to the adenoma to carcinoma sequence, colorectal carcinogenesis can occur via
the serrated pathway. Studies have focused on clarification of categories and molecular …
the serrated pathway. Studies have focused on clarification of categories and molecular …
The molecular hallmarks of the serrated pathway in colorectal cancer
Colorectal cancer (CRC) is a leading cause of cancer death worldwide. It includes different
subtypes that differ in their clinical and prognostic features. In the past decade, in addition to …
subtypes that differ in their clinical and prognostic features. In the past decade, in addition to …
Diagnosis of Lynch syndrome and strategies to distinguish Lynch-related tumors from sporadic MSI/dMMR tumors
J Leclerc, C Vermaut, MP Buisine - Cancers, 2021 - mdpi.com
Simple Summary Microsatellite instability (MSI) is a hallmark of Lynch syndrome (LS)-related
tumors but is not specific, as most of MSI/mismatch repair-deficient (dMMR) tumors are …
tumors but is not specific, as most of MSI/mismatch repair-deficient (dMMR) tumors are …
Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis
Objective Serrated colorectal cancer (CRC) accounts for approximately 25% of cases and
includes tumours that are among the most treatment resistant and with worst outcomes. This …
includes tumours that are among the most treatment resistant and with worst outcomes. This …
Serrated colorectal cancer: Preclinical models and molecular pathways
Serrated lesions are histologically heterogeneous, and detection can be challenging as
these lesions have subtle features that may be missed by endoscopy. Furthermore, while …
these lesions have subtle features that may be missed by endoscopy. Furthermore, while …
Tumour heterogeneity and evolutionary dynamics in colorectal cancer
DKH Chan, SJA Buczacki - Oncogenesis, 2021 - nature.com
Colorectal cancer (CRC) has a global burden of disease. Our current understanding of CRC
has progressed from initial discoveries which focused on the stepwise accumulation of key …
has progressed from initial discoveries which focused on the stepwise accumulation of key …
Wnt signaling in cancer: not a binary ON: OFF switch
In the March 1 issue of Cancer Research, we identified the Wnt receptor Fzd7 as an
attractive therapeutic target for the treatment of gastric cancer. In summary, we showed that …
attractive therapeutic target for the treatment of gastric cancer. In summary, we showed that …
BRAF and AXL oncogenes drive RIPK3 expression loss in cancer
Necroptosis is a lytic programmed cell death mediated by the RIPK1-RIPK3-MLKL pathway.
The loss of Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) expression and …
The loss of Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) expression and …
Sex difference of colon adenoma pathway and colorectal carcinogenesis
Y Choi, N Kim - The World Journal of Men's Health, 2023 - pmc.ncbi.nlm.nih.gov
Colorectal cancer (CRC) is one of the most common causes of cancer morbidity in both
sexes but shows sex differences. First, sex-specific differences in tumor recurrence and …
sexes but shows sex differences. First, sex-specific differences in tumor recurrence and …
Serrated colorectal cancer: the road less travelled?
Studies of colorectal cancer (CRC) originating through the conventional adenoma-
carcinoma sequence have provided insight into the molecular mechanisms controlling its …
carcinoma sequence have provided insight into the molecular mechanisms controlling its …