Biofilms—matrix-enclosed microbial accretions that adhere to biological or non-biological
surfaces—represent a significant and incompletely understood mode of growth for bacteria …

Concern over antibiotic resistance is growing, and new classes of antibiotics, particularly
against Gram-negative bacteria, are needed. However, even if the scientific hurdles can be …

Background: It has been recognized for more than 20 years that the macrolides have
immunomodulatory effects that are beneficial for those suffering from chronic pulmonary …

Bacteria have traditionally been regarded as individual organisms growing in homogeneous
planktonic populations. However, bacteria in natural environments usually form communities …

Now that basic research has demonstrated that the vast majority of bacteria exist in biofilms,
the biofilm concept of disease is beginning to spread throughout the clinical world …

Long-term therapy with the macrolide antibiotic erythromycin was shown to alter the clinical
course of diffuse panbronchiolitis in the late 1980s. Since that time, macrolides have been …

Macrolide antibiotics possess several, beneficial, secondary properties which complement
their primary antimicrobial activity. In addition to high levels of tissue penetration, which may …

Background: The questions of whether the use of antibiotics that are active against atypical
organisms is beneficial in the treatment of community-acquired pneumonia and of the …

Azithromycin Retards Pseudomonas aeruginosa Biofilm Formation | Journal of Clinical
Microbiology CLOSE This Journal Anywhere Enter words / phrases / DOI / ISBN / keywords …

Chronic obstructive pulmonary disease (COPD) is a leading cause of death and disability
worldwide. The Global Burden of Disease study has concluded that COPD will become the …