Beyond their fundamental role in hemostasis, platelets importantly contribute to other
processes aimed at maintaining homeostasis. Indeed, platelets are a natural source of …

Tissue factor (TF) plays a central role in haemostasis and thrombosis. Following vascular
damage, vessel wall TF initiates the extrinsic coagulation cascade. TF can also be exposed …

Von Willebrand factor (VWF) is a glycoprotein synthesized and secreted by vascular
endothelial cells and megakaryocytes, found on plasma surface, endothelial cells, and α …

Staphylococcus aureus is a leading cause of endovascular infections. This bacterial
pathogen uses a diverse array of surface adhesins to clump in blood and adhere to vessel …

Resting platelets rely on oxidative phosphorylation (OXPHOS) and aerobic glycolysis
(conversion of glucose to lactate in the presence of oxygen) to generate adenosine …

BACKGROUND Thromboembolic events within the pulmonary arterial vasculature are a
troublesome complication of severe blunt thoracic trauma. Mechanisms underlying these …

The ferric chloride models of arterial thrombosis are useful tools with which to investigate the
cellular and molecular mechanisms that contribute to arterial thrombosis. Recent insights …

Objective—RalA and RalB GTPases are important regulators of cell growth, cancer
metastasis, and granule secretion. The purpose of this study was to determine the role of Ral …

All eukaryotic cells can secrete extracellular vesicles, which have a double-membrane
structure and are important players in the intercellular communication involved in a variety of …

An early and accurate diagnosis of pulmonary thromboembolism (PTE) remains
challenging. The present study aimed to evaluate the diagnostic value of platelet‑derived …