Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and
anabolism to generate cellular energy and structural components. The emerging field of …

Multiple modes of cell death have been identified, each with a unique function and each
induced in a setting-dependent manner. As billions of cells die during mammalian …

Obesity and hypertension, which often coexist, are major risk factors for heart failure and are
characterized by chronic, low-grade inflammation, which promotes adverse cardiac …

Profound metabolic changes are characteristic of macrophages during classical activation
and have been implicated in this phenotype. Here we demonstrate that nitric oxide (NO) …

Immunometabolism has emerged as a major mechanism central to adaptive and innate
immune regulation. From early observations that inflammatory cytokines were induced in …

Resolving-type macrophages prevent chronic inflammation by clearing apoptotic cells
through efferocytosis. These macrophages are thought to rely mainly on oxidative …

Efficient inflammation resolution is important not only for the termination of the inflammatory
response but also for the restoration of tissue integrity. An integral process to resolution of …

Nearly every tissue in the body undergoes routine turnover of cells as part of normal healthy
living. The majority of these cells undergoing turnover die via apoptosis, and then are rapidly …

Obesity-associated inflammation is a systemic process that affects all metabolic organs.
Prominent among these is adipose tissue, where cells of the innate and adaptive immune …

Resolution is an active and highly coordinated process that occurs in response to
inflammation to limit tissue damage and promote repair. When the resolution program fails …