Forty years of molecular diagnostics for infectious diseases

JE Schmitz, CW Stratton, DH Persing… - Journal of clinical …, 2022 - journals.asm.org
Nearly 40 years have elapsed since the invention of the PCR, with its extremely sensitive
and specific ability to detect nucleic acids via in vitro enzyme-mediated amplification. In turn …

Symptoms, risk factors, diagnosis and treatment of urinary tract infections

R Kaur, R Kaur - Postgraduate medical journal, 2021 - academic.oup.com
Urinary tract infection (UTI) is a common microbial infection found in all ages and sexes
which involves inflammation of the urinary tract. These infections can range from simple …

[HTML][HTML] Molecular diagnostic methods versus conventional urine culture for diagnosis and treatment of urinary tract infection: a systematic review and meta-analysis

A Szlachta-McGinn, KM Douglass, UYR Chung… - European Urology Open …, 2022 - Elsevier
Context Urine culture has low sensitivity in the diagnosis of urinary tract infection (UTI). Next-
generation sequencing (NGS) and polymerase chain reaction (PCR) are culture …

A guide for urogynecologic patient care utilizing telemedicine during the COVID-19 pandemic: review of existing evidence

CL Grimes, EM Balk, CC Crisp, DD Antosh… - International …, 2020 - Springer
Introduction and hypothesis The COVID-19 pandemic and the desire to “flatten the curve” of
transmission have significantly affected the way providers care for patients. Female Pelvic …

A new gold rush: a review of current and develo** diagnostic tools for urinary tract infections

R Xu, N Deebel, R Casals, R Dutta, M Mirzazadeh - Diagnostics, 2021 - mdpi.com
Urinary tract infections (UTIs) are one of the most common infections in the United States
and consequently are responsible for significant healthcare expenditure. The standard urine …

Urine biomarkers individually and as a consensus model show high sensitivity and specificity for detecting UTIs

M Akhlaghpour, E Haley, L Parnell, N Luke… - BMC Infectious …, 2024 - Springer
Background Current diagnoses of urinary tract infection (UTI) by standard urine culture
(SUC) has significant limitations in sensitivity, especially for fastidious organisms, and the …

[HTML][HTML] Improving patient outcomes while reducing empirical treatment with multiplex-polymerase-chain-reaction/pooled-antibiotic-susceptibility-testing assay for …

E Haley, N Luke, H Korman, D Baunoch, D Wang… - Diagnostics, 2023 - mdpi.com
This study compared rates of empirical-therapy use and negative patient outcomes between
complicated and recurrent urinary tract infection (r/cUTI) cases diagnosed with a multiplex …

[HTML][HTML] Current and future molecular diagnostics of tick-borne diseases in cattle

K Garcia, M Weakley, T Do, S Mir - Veterinary Sciences, 2022 - mdpi.com
Ticks and tick-borne diseases such as babesiosis, anaplasmosis, ehrlichiosis, Lyme
disease, Crimean Congo hemorrhagic fever, and Rocky Mountain spotted fever pose a …

The prevalence and association of different uropathogens detected by M-PCR with infection-associated urine biomarkers in urinary tract infections

E Haley, N Luke, M Mathur, RA Festa… - … and Reports in …, 2024 - Taylor & Francis
Background Many emerging uropathogens are currently identified by multiplex polymerase
chain reaction (M-PCR) in suspected UTI cases. Standard urine culture (SUC) has …

[HTML][HTML] Rising prevalence of multidrug-resistant uropathogenic bacteria from urinary tract infections in pregnant women

U Asmat, MZ Mumtaz, A Malik - Journal of Taibah University Medical …, 2021 - Elsevier
Objectives This study aimed to determine the prevalence of urinary tract infections (UTI) in
pregnant women and characterise the uropathogenic bacterial strains associated with …