Strategies to improve the EPR effect: A mechanistic perspective and clinical translation
Many efforts have been made to achieve targeted delivery of anticancer drugs to enhance
their efficacy and to reduce their adverse effects. These efforts include the development of …
their efficacy and to reduce their adverse effects. These efforts include the development of …
[HTML][HTML] The role of VEGF in cancer-induced angiogenesis and research progress of drugs targeting VEGF
S Ghalehbandi, J Yuzugulen, MZI Pranjol… - European Journal of …, 2023 - Elsevier
Angiogenesis is a double-edged sword; it is a mechanism that defines the boundary
between health and disease. In spite of its central role in physiological homeostasis, it …
between health and disease. In spite of its central role in physiological homeostasis, it …
[HTML][HTML] Green synthesis of gold nanoparticles via Capsicum annum fruit extract: characterization, antiangiogenic, antioxidant and anti-inflammatory activities
Biological synthesis of gold nanoparticles (AuNPs) is gaining attention of researchers
because of their varieties of biomedical applications. This study reported the novel, eco …
because of their varieties of biomedical applications. This study reported the novel, eco …
The role of inflammation and therapeutic concepts in diabetic retinopathy—a short review
K Gomułka, M Ruta - International Journal of Molecular Sciences, 2023 - mdpi.com
Diabetic retinopathy (DR) as a microangiopathy is the most common complication in patients
with diabetes mellitus (DM) and remains the leading cause of blindness among adult …
with diabetes mellitus (DM) and remains the leading cause of blindness among adult …
Antispasmodic activity of carnosic acid extracted from rosmarinus officinalis: Isolation, spectroscopic characterization, DFT studies, and in silico molecular docking …
This research work focuses on the isolation, spectroscopic characterization (FT-IR, UV–vis,
and NMR), density functional theory (DFT) studies, and the potential application of carnosic …
and NMR), density functional theory (DFT) studies, and the potential application of carnosic …
The immunometabolic ecosystem in cancer
GR Bantug, C Hess - Nature Immunology, 2023 - nature.com
Our increased understanding of how key metabolic pathways are activated and regulated in
malignant cells has identified metabolic vulnerabilities of cancers. Translating this insight to …
malignant cells has identified metabolic vulnerabilities of cancers. Translating this insight to …
Current status and advances of immunotherapy in nasopharyngeal carcinoma
JY Xu, XL Wei, YQ Wang… - Therapeutic Advances in …, 2022 - journals.sagepub.com
The general immune landscape of nasopharyngeal carcinoma (NPC) renders
immunotherapy suitable for patients with NPC. Immune checkpoint inhibitors (ICIs) based on …
immunotherapy suitable for patients with NPC. Immune checkpoint inhibitors (ICIs) based on …
Resha** of the tumor microenvironment by cellular senescence: an opportunity for senotherapies
M D'Ambrosio, J Gil - Developmental Cell, 2023 - cell.com
Cellular senescence is a stress response associated with aging and disease, including
cancer. Senescent cells undergo a stable cell cycle arrest, undergo a change in morphology …
cancer. Senescent cells undergo a stable cell cycle arrest, undergo a change in morphology …
[HTML][HTML] Molecular mechanisms targeting drug-resistance and metastasis in colorectal cancer: Updates and beyond
S Al Bitar, M El-Sabban, S Doughan… - World Journal of …, 2023 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is the third most diagnosed malignancy and a major leading cause
of cancer-related deaths worldwide. Despite advances in therapeutic regimens, the number …
of cancer-related deaths worldwide. Despite advances in therapeutic regimens, the number …
Roles of TGF-β signals in tumor microenvironment via regulation of the formation and plasticity of vascular system
Tumor cells evolve in tumor microenvironment composed of multiple cell types. Among
these, endothelial cells (ECs) are the major players in tumor angiogenesis, which is a driver …
these, endothelial cells (ECs) are the major players in tumor angiogenesis, which is a driver …