Strategies to improve the EPR effect: A mechanistic perspective and clinical translation

M Ikeda-Imafuku, LLW Wang, D Rodrigues… - Journal of Controlled …, 2022 - Elsevier
Many efforts have been made to achieve targeted delivery of anticancer drugs to enhance
their efficacy and to reduce their adverse effects. These efforts include the development of …

[HTML][HTML] The role of VEGF in cancer-induced angiogenesis and research progress of drugs targeting VEGF

S Ghalehbandi, J Yuzugulen, MZI Pranjol… - European Journal of …, 2023 - Elsevier
Angiogenesis is a double-edged sword; it is a mechanism that defines the boundary
between health and disease. In spite of its central role in physiological homeostasis, it …

[HTML][HTML] Green synthesis of gold nanoparticles via Capsicum annum fruit extract: characterization, antiangiogenic, antioxidant and anti-inflammatory activities

TP Patil, AA Vibhute, SL Patil, TD Dongale… - Applied Surface Science …, 2023 - Elsevier
Biological synthesis of gold nanoparticles (AuNPs) is gaining attention of researchers
because of their varieties of biomedical applications. This study reported the novel, eco …

The role of inflammation and therapeutic concepts in diabetic retinopathy—a short review

K Gomułka, M Ruta - International Journal of Molecular Sciences, 2023 - mdpi.com
Diabetic retinopathy (DR) as a microangiopathy is the most common complication in patients
with diabetes mellitus (DM) and remains the leading cause of blindness among adult …

Antispasmodic activity of carnosic acid extracted from rosmarinus officinalis: Isolation, spectroscopic characterization, DFT studies, and in silico molecular docking …

K Wei, H Louis, W Emori, PS Idante… - Journal of Molecular …, 2022 - Elsevier
This research work focuses on the isolation, spectroscopic characterization (FT-IR, UV–vis,
and NMR), density functional theory (DFT) studies, and the potential application of carnosic …

The immunometabolic ecosystem in cancer

GR Bantug, C Hess - Nature Immunology, 2023 - nature.com
Our increased understanding of how key metabolic pathways are activated and regulated in
malignant cells has identified metabolic vulnerabilities of cancers. Translating this insight to …

Current status and advances of immunotherapy in nasopharyngeal carcinoma

JY Xu, XL Wei, YQ Wang… - Therapeutic Advances in …, 2022 - journals.sagepub.com
The general immune landscape of nasopharyngeal carcinoma (NPC) renders
immunotherapy suitable for patients with NPC. Immune checkpoint inhibitors (ICIs) based on …

Resha** of the tumor microenvironment by cellular senescence: an opportunity for senotherapies

M D'Ambrosio, J Gil - Developmental Cell, 2023 - cell.com
Cellular senescence is a stress response associated with aging and disease, including
cancer. Senescent cells undergo a stable cell cycle arrest, undergo a change in morphology …

[HTML][HTML] Molecular mechanisms targeting drug-resistance and metastasis in colorectal cancer: Updates and beyond

S Al Bitar, M El-Sabban, S Doughan… - World Journal of …, 2023 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is the third most diagnosed malignancy and a major leading cause
of cancer-related deaths worldwide. Despite advances in therapeutic regimens, the number …

Roles of TGF-β signals in tumor microenvironment via regulation of the formation and plasticity of vascular system

T Watabe, K Takahashi, K Pietras… - Seminars in Cancer …, 2023 - Elsevier
Tumor cells evolve in tumor microenvironment composed of multiple cell types. Among
these, endothelial cells (ECs) are the major players in tumor angiogenesis, which is a driver …