Intracellular lifestyle of Chlamydia trachomatis and host–pathogen interactions

K Stelzner, N Vollmuth, T Rudel - Nature Reviews Microbiology, 2023 - nature.com
In recent years, substantial progress has been made in the understanding of the intracellular
lifestyle of Chlamydia trachomatis and how the bacteria establish themselves in the human …

Genome organization and genomics in Chlamydia: whole genome sequencing increases understanding of chlamydial virulence, evolution, and phylogeny

LDW Luu, V Kasimov, S Phillips, GSA Myers… - Frontiers in cellular …, 2023 - frontiersin.org
The genus Chlamydia contains important obligate intracellular bacterial pathogens to
humans and animals, including C. trachomatis and C. pneumoniae. Since 1998, when the …

Chlamydial plasmid-dependent pathogenicity

G Zhong - Trends in microbiology, 2017 - cell.com
Most Chlamydia species carry a 7.5 kb plasmid encoding eight open reading frames
conventionally called plasmid glycoproteins 1–8 or pGP1–8. Although the plasmid is not …

Chlamydia trachomatis genital tract infections: when host immune response and the microbiome collide

N Ziklo, WM Huston, JS Hocking, P Timms - Trends in microbiology, 2016 - cell.com
Genital infections with Chlamydia trachomatis continue to be a major health problem
worldwide. While some individuals clear their infection (presumed to be the result of an …

Pathology after Chlamydia trachomatis infection is driven by nonprotective immune cells that are distinct from protective populations

RS Lijek, JD Helble, AJ Olive, KW Seiger… - Proceedings of the …, 2018 - pnas.org
Infection with Chlamydia trachomatis drives severe mucosal immunopathology; however,
the immune responses that are required for mediating pathology vs. protection are not well …

Chlamydia trachomatis Serovars Drive Differential Production of Proinflammatory Cytokines and Chemokines Depending on the Type of Cell Infected

R Faris, SE Andersen, A McCullough… - Frontiers in cellular …, 2019 - frontiersin.org
Chlamydia trachomatis serovars AC infect conjunctival epithelial cells and untreated
infection can lead to blindness. DK infect genital tract epithelial cells resulting in pelvic …

The role of infected epithelial cells in Chlamydia-associated fibrosis

LT Caven, RA Carabeo - Frontiers in Cellular and Infection …, 2023 - frontiersin.org
Ocular, genital, and anogenital infection by the obligate intracellular pathogen Chlamydia
trachomatis have been consistently associated with scar-forming sequelae. In cases of …

Chlamydia and Its Many Ways of Esca** the Host Immune System

WF Wong, JP Chambers, R Gupta… - Journal of …, 2019 - Wiley Online Library
The increasing number of new cases of Chlamydia infection worldwide may be attributed to
the pathogen's ability to evade various host immune responses. Summarized here are …

Overexpressing the ClpC AAA+ unfoldase accelerates developmental cycle progression in Chlamydia trachomatis

AA Jensen, S Firdous, L Lei, DJ Fisher, SP Ouellette - Mbio, 2025 - journals.asm.org
Chlamydia is an obligate intracellular bacterium that undergoes a complex biphasic
developmental cycle, alternating between the smaller, infectious, non-dividing elementary …

Proximity-dependent proteomics of the Chlamydia trachomatis inclusion membrane reveals functional interactions with endoplasmic reticulum exit sites

MS Dickinson, LN Anderson… - PLoS …, 2019 - journals.plos.org
Chlamydia trachomatis is the most common cause of bacterial sexually transmitted infection,
responsible for millions of infections each year. Despite this high prevalence, the elucidation …