Integrative structure determination is a powerful approach to modeling the structures of
biological systems based on data produced by multiple experimental and theoretical …

Crosslinking mass spectrometry (crosslinking-MS) is a versatile tool providing structural
insights into protein conformation and protein-protein interactions. Its medium-resolution …

We describe a general approach for refining protein structure models on the basis of cryo-
electron microscopy maps with near-atomic resolution. The method integrates Monte Carlo …

Introduction to Proteins provides a comprehensive and state-of-the-art introduction to the
structure, function, and motion of proteins for students, faculty, and researchers at all levels …

Knowledge of protein structure is paramount to the understanding of biological function,
develo** new therapeutics, and making detailed mechanistic hypotheses. Therefore …

Advances in cryo-electron microscopy (cryo-EM) imaging technologies have led to a rapidly
increasing number of cryo-EM density maps. Alignment and comparison of density maps …

Essential processes in biology are carried out by large macromolecular assemblies, whose
structures are often difficult to determine by traditional methods. Increasingly, researchers …

Electron density maps of membrane proteins or large macromolecular complexes are
frequently only determined at medium resolution between 4 Å and 10 Å, either by cryo …

Recent developments in 3-dimensional electron microcopy (3D-EM) techniques and a
concomitant drive to look at complex molecular structures, have led to a rapid increase in the …

Cryo-electron microscopy (cryo-EM) has now become a widely used technique for structure
determination of macromolecular complexes. For modeling molecular structures from …