The pe/ppe genes represent one of the most intriguing aspects of the M ycobacterium
tuberculosis genome. These genes are especially abundant in pathogenic mycobacteria …

Rapid adaptation to changing environments is one of the keys of the success of
microorganisms. Such adaptation is achieved by enabling different strategies, the most …

A major constraint for develo** new anti-tuberculosis drugs is the limited number of
validated targets that allow eradication of persistent infections. Here, we uncover a …

Oxygen availability is a major factor and evolutionary force determining the metabolic
strategy of bacteria colonizing an environmental niche. In the soil, conditions can switch …

Bacterial endospores are the most resistant cell type known to humans, as they are able to
withstand extremes of temperature, pressure, chemical injury, and time. They are also of …

The ability of Mycobacterium tuberculosis to infect, proliferate, and survive during long
periods in the human lungs largely depends on the rigorous control of gene expression …

Inorganic polyphosphate (polyP), a linear polymer of hundreds of phosphate residues linked
by ATP-like phosphoanhydride bonds, is found in all organisms and performs a wide variety …

Mycobacterium tuberculosis, the causative agent of tuberculosis, accounts for 1.5 million
human deaths annually worldwide. Despite efforts to eradicate tuberculosis, it still remains a …

Tuberculosis (TB) treatment is hampered by the long duration of antibiotic therapy required
to achieve cure. This indolent response has been partly attributed to the ability of …

The soil bacterium Mycobacterium smegmatis is able to scavenge the trace concentrations
of H2 present in the atmosphere, but the physiological function and importance of this …