Bipolar disorder (BD) is one of the most heritable mental illnesses, but the elucidation of its
genetic basis has proven to be a very challenging endeavor. Genome-Wide Association …

Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-
wide association study of 41,917 bipolar disorder cases and 371,549 controls of European …

Importance Compared with non-Hispanic White individuals, African American individuals
from the same community are approximately twice as likely to develop Alzheimer disease …

Over the past decades, genome-wide association studies (GWAS) have identified thousands
of phenotype-associated DNA sequence variants for potential explanations of inter …

Genome-wide association studies (GWAS) of Alzheimer's disease are predominantly carried
out in European ancestry individuals despite the known variation in genetic architecture and …

Kleine-Levin syndrome (KLS) is a rare disorder characterized by severe episodic
hypersomnia, with cognitive impairment accompanied by apathy or disinhibition …

Bipolar disorder (BD) is a heritable mental illness with complex etiology. We performed a
genome-wide association study (GWAS) of 41,917 BD cases and 371,549 controls of …

The genetic architecture of each individual comprises common and rare variants that, acting
alone and in combination, confer risk of disease. The cell-type-specific and/or context …

Regardless of which of the mechanisms described here plays a primary or secondary role in
the pathophysiology of bipolar disorder, all of these interact to worsen clinical outcomes for …

Bipolar disorder (BD) and schizophrenia are psychiatric disorders that manifest unusual
mental, behavioral, and emotional patterns leading to suffering and disability. These …