Recently, the International Association for the Study of Pain (IASP) released clinical criteria
and a grading system for nociplastic pain affecting the musculoskeletal system. These …

Different neuroplastic processes can occur along the nociceptive pathways and may be
important in the transition from acute to chronic pain and for diagnosis and development of …

Accurate classification of chronic pain conditions requires reliable and valid pain
assessment. Moreover, pain assessment serves several additional functions, including …

Objective Emerging evidence suggests that pain sensitization plays an important role in pain
associated with knee osteoarthritis (OA). This systematic review and meta-analysis …

Abstract Background Knee Osteoarthritis (KOA) is a heterogeneous pathology characterized
by a complex and multifactorial nature. It has been hypothesised that these differences are …

Objective Pain sensitization is associated with pain severity in knee osteoarthritis (OA), but
its cause in humans is not well understood. We examined whether inflammation, assessed …

Treating chronic musculoskeletal pain, and chronic joint pain (osteoarthritis (OA)) in
particular, is challenging as the peripheral and central pain mechanisms are not fully …

Osteoarthritis (OA), a leading cause of disability and pain, affects 32.5 million Americans,
producing tremendous economic burden. Although some findings suggest that racial/ethnic …

1. Background Osteoarthritis is a leading cause of chronic pain, and when painful
osteoarthritis cannot be managed in primary care, joint replacement surgery is often …

Objective Symptomatic knee osteoarthritis (OA) is a condition commonly associated with
increased pain, disability, and functional limitations. Given the poor correspondence …