The pathogenesis of gout: molecular insights from genetic, epigenomic and transcriptomic studies
The pathogenesis of gout involves a series of steps beginning with hyperuricaemia, followed
by the deposition of monosodium urate crystal in articular structures and culminating in an …
by the deposition of monosodium urate crystal in articular structures and culminating in an …
GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic background
Genome-wide association studies (GWAS) have been used to study the genetic basis of a
wide variety of complex diseases and other traits. We describe UK Biobank GWAS results for …
wide variety of complex diseases and other traits. We describe UK Biobank GWAS results for …
Sex differences in urate handling
VL Halperin Kuhns, OM Woodward - International journal of molecular …, 2020 - mdpi.com
Hyperuricemia, or elevated serum urate, causes urate kidney stones and gout and also
increases the incidence of many other conditions including renal disease, cardiovascular …
increases the incidence of many other conditions including renal disease, cardiovascular …
Why does hyperuricemia not necessarily induce gout?
WZ Zhang - Biomolecules, 2021 - mdpi.com
Hyperuricemia is a risk factor for gout. It has been well observed that a large proportion of
individuals with hyperuricemia have never had a gout flare (s), while some patients with gout …
individuals with hyperuricemia have never had a gout flare (s), while some patients with gout …
An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility
Background While genome-wide associations studies (GWAS) have successfully elucidated
the genetic architecture of complex human traits and diseases, understanding mechanisms …
the genetic architecture of complex human traits and diseases, understanding mechanisms …
Genome-wide association study of CKD progression
Background Rapid progression of CKD is associated with poor clinical outcomes. Despite
extensive study of the genetics of cross-sectional eGFR, only a few loci associated with …
extensive study of the genetics of cross-sectional eGFR, only a few loci associated with …
Hepatic solute carrier transporters and drug therapy: Regulation of expression and impact of genetic variation
Organic cation transporters (OCT), organic anion transporting polypeptides (OATP) and
organic anion transporters (OAT) from the solute carrier (SLC) family play an essential role …
organic anion transporters (OAT) from the solute carrier (SLC) family play an essential role …
Molecular pathophysiology of uric acid homeostasis
C Estiverne, AK Mandal, DB Mount - Seminars in nephrology, 2020 - Elsevier
Uric acid, the end product of purine metabolism, plays a key role in the pathogenesis of gout
and other disease processes. The circulating serum uric acid concentration is governed by …
and other disease processes. The circulating serum uric acid concentration is governed by …
Advances in our understanding of gout as an auto-inflammatory disease
Gout, the most common inflammatory arthritis, is the result of hyperuricemia and
inflammation induced by monosodium urate (MSU) crystal deposition. However, most …
inflammation induced by monosodium urate (MSU) crystal deposition. However, most …
Genetic and physiological effects of insulin-like growth factor-1 (IGF-1) on human urate homeostasis
Background Metabolic syndrome and hyperinsulinemia are associated with hyperuricemia.
Insulin infusion in healthy volunteers elevates serum urate (SU) by activating net urate …
Insulin infusion in healthy volunteers elevates serum urate (SU) by activating net urate …