Shared molecular mechanisms of membrane transporters

D Drew, O Boudker - Annual review of biochemistry, 2016 - annualreviews.org
The determination of the crystal structures of small-molecule transporters has shed light on
the conformational changes that take place during structural isomerization from outward-to …

Biology of human sodium glucose transporters

EM Wright, DDF Loo, BA Hirayama - Physiological reviews, 2011 - journals.physiology.org
There are two classes of glucose transporters involved in glucose homeostasis in the body,
the facilitated transporters or uniporters (GLUTs) and the active transporters or symporters …

Molecular pumps and motors

Y Feng, M Ovalle, JSW Seale, CK Lee… - Journal of the …, 2021 - ACS Publications
Pumps and motors are essential components of the world as we know it. From the complex
proteins that sustain our cells, to the mechanical marvels that power industries, much we …

Molecular basis for redox control by the human cystine/glutamate antiporter system xc

JL Parker, JC Deme, D Kolokouris, G Kuteyi… - Nature …, 2021 - nature.com
Cysteine plays an essential role in cellular redox homoeostasis as a key constituent of the
tripeptide glutathione (GSH). A rate limiting step in cellular GSH synthesis is the availability …

[HTML][HTML] The ABCs of membrane transporters in health and disease (SLC series): introduction

MA Hediger, B Clémençon, RE Burrier… - Molecular aspects of …, 2013 - Elsevier
The field of transport biology has steadily grown over the past decade and is now
recognized as playing an important role in manifestation and treatment of disease. The SLC …

SLC6 neurotransmitter transporters: structure, function, and regulation

AS Kristensen, J Andersen, TN Jørgensen… - Pharmacological …, 2011 - Elsevier
The neurotransmitter transporters (NTTs) belonging to the solute carrier 6 (SLC6) gene
family (also referred to as the neurotransmitter-sodium-symporter family or Na+/Cl …

[LIBRO][B] Bioenergetics

DG Nicholls - 2013 - books.google.com
Extensively revised, the fourth edition of this highly successful book takes into account the
many newly determined protein structures that provide molecular insight into chemiosmotic …

X-ray structures of LeuT in substrate-free outward-open and apo inward-open states

H Krishnamurthy, E Gouaux - Nature, 2012 - nature.com
Neurotransmitter sodium symporters are integral membrane proteins that remove chemical
transmitters from the synapse and terminate neurotransmission mediated by serotonin …

Crystal structure of the anion exchanger domain of human erythrocyte band 3

T Arakawa, T Kobayashi-Yurugi, Y Alguel, H Iwanari… - Science, 2015 - science.org
Anion exchanger 1 (AE1), also known as band 3 or SLC4A1, plays a key role in the removal
of carbon dioxide from tissues by facilitating the exchange of chloride and bicarbonate …

SLC6 transporters: structure, function, regulation, disease association and therapeutics

AB Pramod, J Foster, L Carvelli, LK Henry - Molecular aspects of medicine, 2013 - Elsevier
The SLC6 family of secondary active transporters are integral membrane solute carrier
proteins characterized by the Na+-dependent translocation of small amino acid or amino …