Sequencing-based methods and resources to study antimicrobial resistance

M Boolchandani, AW D'Souza, G Dantas - Nature Reviews Genetics, 2019 - nature.com
Antimicrobial resistance extracts high morbidity, mortality and economic costs yearly by
rendering bacteria immune to antibiotics. Identifying and understanding antimicrobial …

Using genomics to track global antimicrobial resistance

RS Hendriksen, V Bortolaia, H Tate, GH Tyson… - Frontiers in public …, 2019 - frontiersin.org
The recent advancements in rapid and affordable DNA sequencing technologies have
revolutionized diagnostic microbiology and microbial surveillance. The availability of …

ResFinder–an open online resource for identification of antimicrobial resistance genes in next-generation sequencing data and prediction of phenotypes from …

AF Florensa, RS Kaas, PTLC Clausen… - Microbial …, 2022 - microbiologyresearch.org
Antimicrobial resistance (AMR) is one of the most important health threats globally. The
ability to accurately identify resistant bacterial isolates and the individual antimicrobial …

Rapid expansion and international spread of M1UK in the post-pandemic UK upsurge of Streptococcus pyogenes

A Vieira, Y Wan, Y Ryan, HK Li, RL Guy… - Nature …, 2024 - nature.com
The UK observed a marked increase in scarlet fever and invasive group A streptococcal
infection in 2022 with severe outcomes in children and similar trends worldwide. Here we …

Characterization of antimicrobial-resistant Gram-negative bacteria that cause neonatal sepsis in seven low-and middle-income countries

K Sands, MJ Carvalho, E Portal, K Thomson… - Nature …, 2021 - nature.com
Antimicrobial resistance in neonatal sepsis is rising, yet mechanisms of resistance that often
spread between species via mobile genetic elements, ultimately limiting treatments in low …

Rapid and precise alignment of raw reads against redundant databases with KMA

PTLC Clausen, FM Aarestrup, O Lund - BMC bioinformatics, 2018 - Springer
Background As the cost of sequencing has declined, clinical diagnostics based on next
generation sequencing (NGS) have become reality. Diagnostics based on sequencing will …

Open-access bacterial population genomics: BIGSdb software, the PubMLST. org website and their applications

KA Jolley, JE Bray, MCJ Maiden - Wellcome open research, 2018 - pmc.ncbi.nlm.nih.gov
The PubMLST. org website hosts a collection of open-access, curated databases that
integrate population sequence data with provenance and phenotype information for over …

Completing bacterial genome assemblies with multiplex MinION sequencing

RR Wick, LM Judd, CL Gorrie… - Microbial …, 2017 - microbiologyresearch.org
Illumina sequencing platforms have enabled widespread bacterial whole genome
sequencing. While Illumina data is appropriate for many analyses, its short read length limits …

ARIBA: rapid antimicrobial resistance genoty** directly from sequencing reads

M Hunt, AE Mather, L Sánchez-Busó… - Microbial …, 2017 - microbiologyresearch.org
Antimicrobial resistance (AMR) is one of the major threats to human and animal health
worldwide, yet few high-throughput tools exist to analyse and predict the resistance of a …

Staphylococcal diversity in atopic dermatitis from an individual to a global scale

SS Kashaf, CP Harkins, C Deming, P Joglekar… - Cell host & …, 2023 - cell.com
Atopic dermatitis (AD) is a multifactorial, chronic relapsing disease associated with genetic
and environmental factors. Among skin microbes, Staphylococcus aureus and …