Importance Systemic lupus erythematosus (SLE) is a chronic autoimmune disease
characterized by inflammation and immune-mediated injury to multiple organ systems …

Chimeric antigen receptor (CAR) T cells are highly effective at targeting and eliminating cells
of the B cell lineage. CAR T cell therapy has become a standard-of-care treatment for …

Objectives To provide an update of the EULAR rheumatoid arthritis (RA) management
recommendations addressing the most recent developments in the field. Methods An …

Lupus nephritis is a common complication of systemic lupus erythematosus (SLE) and a
determinant of overall morbidity and mortality, as lupus nephritis-related chronic kidney …

Objective Our objective was to evaluate the effect of glucocorticoid regimens on renal
response, infections, and mortality among patients with lupus nephritis (LN). Methods We …

Objective The 48‐week, phase 2 SLEek study (NCT03978520) evaluated the efficacy and
safety of upadacitinib (JAK inhibitor) and elsubrutinib (BTK inhibitor) alone or in combination …

Systemic lupus erythematosus (SLE) is a prime example of how the interplay between
genetic and environmental factors can trigger systemic autoimmunity, particularly in young …

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease in which immune
disorders lead to autoreactive immune responses and cause inflammation and tissue …

B cells have a pivotal function in the pathogenesis of autoimmune diseases, such as
rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus. In autoimmune …

Autoimmune inflammation is caused by the loss of tolerance to specific self-antigens and
can result in organ-specific or systemic disorders. Systemic autoimmune diseases affect a …