Squamous cell carcinoma (SCC) is an aggressive malignancy that can originate from
various organs. TP63 is a master regulator that plays an essential role in epidermal …

Arrhythmogenic cardiomyopathy has been clinically defined since the 1980s and causes
right or biventricular cardiomyopathy associated with ventricular arrhythmia. Although it is a …

The assembly of the embryo's primary axis is a fundamental landmark for the establishment
of the vertebrate body plan. Although the morphogenetic movements directing cell …

Deuterostomes are one major group of bilaterians composed by hemichordates and
echinoderms (collectively called Ambulacraria) and chordates. Comparative studies …

Coordinated chromatin interactions between enhancers and promoters are critical for gene
regulation. The architectural protein CTCF mediates chromatin loo** and is enriched at …

Bone Morphogenetic Protein (BMP) patterns the dorsal–ventral (DV) embryonic axis in all
vertebrates, but it is unknown how cells along the DV axis interpret and translate the …

The lung exhibits a robust, multifaceted regenerative response to severe injuries such as
influenza infection, during which quiescent lung-resident epithelial progenitors participate in …

Activation of transcription factors is a key driver event in cancer. We and others have recently
reported that the Krüppel-like transcription factor KLF5 is activated in multiple epithelial …

Background Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are
syndromes of acute respiratory failure with extremely high mortality and few effective …

The transcription factor p63 is a master regulator of multiple ectodermal derivatives. During
epidermal commitment, p63 interacts with several chromatin remodeling complexes to …