Stroke and late-onset Alzheimer's disease (AD) are risk factors for each other; the
comorbidity of these brain disorders in aging individuals represents a significant challenge …

Methamphetamine (METH) is a popular new-type psychostimulant drug with complicated
neurotoxicity. In spite of mounting evidence on METH-induced damage of neural cell, the …

Geroscience offers a counterpoint to the challenged pursuit of curing diseases of aging, by
focusing on slowing the biological aging process for extended healthspan earlier in life …

Hypoxia is a central pathophysiological component in cancer, myocardial infarction and
ischemic stroke, which represent the most common medical conditions resulting in long-term …

As the organ with the highest demand for oxygen, the brain has a poor tolerance to ischemia
and hypoxia. Despite severe ischemia/hypoxia induces the occurrence and development of …

Background The outbreak of a novel coronavirus since December 2019, became an
emergency of major international concern. As of June 21, 2020, the SARS-CoV-2 pandemic …

Background Remote ischemic preconditioning (RIPC) initiates endogenous protective
pathways in the brain from a distance and represents a new, promising paradigm in …

Traumatic brain injury (TBI) is distinct from other neurological disorders because it is
induced by a discrete event that applies extreme mechanical forces to the brain. This review …

Abstract Bromodomain-containing protein 4 (BRD4), a member of the bromodomain and
extra-terminal domain (BET) protein family, plays a crucial role in regulating inflammation …

Background Postoperative delirium (POD) is a common surgical complication associated
with increased morbidity and mortality in elderly. Although the underlying mechanisms …