Cancer arises from genetic alterations that invariably lead to dysregulated transcriptional
programs. These dysregulated programs can cause cancer cells to become highly …

Recent major advances in understanding the molecular basis of acute myeloid leukemia
(AML) provide a double-edged sword. Although defining the topology and key features of …

Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to
understand mechanisms underpinning gene regulation and disease. In the present study …

Genome function, replication, integrity, and propagation rely on the dynamic structural
organization of chromosomes during the cell cycle. Genome folding in interphase provides …

Genetic variation associated with disease often appears in non-coding parts of the genome.
Understanding the mechanisms by which this phenomenon leads to disease is necessary to …

The spatial organization of chromosomes has long been connected to their polymeric nature
and is believed to be important for their biological functions, including the control of …

STAT3 and STAT5 proteins are oncogenic downstream mediators of the JAK–STAT
pathway. Deregulated STAT3 and STAT5 signaling promotes cancer cell proliferation and …

Cohesin is important for 3D genome organization. Nevertheless, even the complete removal
of cohesin has surprisingly little impact on steady-state gene transcription and enhancer …

Hematopoietic stem cells (HSC) sustain blood production over the entire life-span of an
organism. It is of extreme importance that these cells maintain self-renewal and …

Transcriptional regulators, including the cohesin complex member STAG2, are recurrently
mutated in cancer. The role of STAG2 in gene regulation, hematopoiesis, and tumor …