The intestinal epithelium acts as a physical barrier that separates the intestinal microbiota
from the host and is critical for preserving intestinal homeostasis. The barrier is formed by …

Abstract CXCL3 (CXC Motif Chemokine 3), a member of the CXC chemokine subfamily,
operates as a potent chemoattractant for neutrophils, thereby orchestrating the recruitment …

KRAS signaling is associated with cancer progression in several cancers. Upregulation of
KRAS signaling is often seen in cancers that harbor high KRAS mutation rate, such as …

In recent years, there has been a significant increase in the study of own and foreign human
factors favoring the development of different types of cancer, including genetic and …

Defective DNA mismatch repair creates a strong mutator phenotype, recognized as
microsatellite instability (MSI). Various next-generation sequencing-based methods for …

Background The intrinsic immuno-ge7nomic characteristics of colorectal cancer cells that
affect tumor biology and shape the tumor immune microenvironment (TIM) are unclear …

Recent studies have shown that genomic instability in tumor cells leads to activation of
inflammatory signaling through the cGAS/STING pathway. In this review, we describe …

Research has confirmed that plasma albumin (Alb), prealbumin (PA) and fibrinogen (Fib)
are involved in regulating the occurrence and development of various tumors. Their levels in …

Immune checkpoint blockade transformed cancer therapy during the last decade. However,
durable responses remain uncommon, early and late relapses occur over the course of …

Background TG02 is a peptide-based cancer vaccine eliciting immune responses to
oncogenic codon 12/13 RAS mutations. This phase 1 clinical trial (NCT02933944) assessed …