Budding yeast as a model organism to study the effects of age
A Denoth Lippuner, T Julou… - FEMS microbiology …, 2014 - academic.oup.com
Although a budding yeast culture can be propagated eternally, individual yeast cells age
and eventually die. The detailed knowledge of this unicellular eukaryotic species as well as …
and eventually die. The detailed knowledge of this unicellular eukaryotic species as well as …
Recent advances in microfluidic devices for single-cell cultivation: methods and applications
Single-cell analysis is essential to improve our understanding of cell functionality from
cellular and subcellular aspects for diagnosis and therapy. Single-cell cultivation is one of …
cellular and subcellular aspects for diagnosis and therapy. Single-cell cultivation is one of …
Life span extension by glucose restriction is abrogated by methionine supplementation: Cross-talk between glucose and methionine and implication of methionine as …
K Zou, S Rouskin, K Dervishi, MA McCormick… - Science …, 2020 - science.org
Caloric restriction (CR) is known to extend life span across species; however, the molecular
mechanisms are not well understood. We investigate the mechanism by which glucose …
mechanisms are not well understood. We investigate the mechanism by which glucose …
Protein biogenesis machinery is a driver of replicative aging in yeast
An integrated account of the molecular changes occurring during the process of cellular
aging is crucial towards understanding the underlying mechanisms. Here, using novel …
aging is crucial towards understanding the underlying mechanisms. Here, using novel …
High-throughput analysis of yeast replicative aging using a microfluidic system
MC Jo, W Liu, L Gu, W Dang… - Proceedings of the …, 2015 - National Acad Sciences
Saccharomyces cerevisiae has been an important model for studying the molecular
mechanisms of aging in eukaryotic cells. However, the laborious and low-throughput …
mechanisms of aging in eukaryotic cells. However, the laborious and low-throughput …
A microfluidic system for studying ageing and dynamic single-cell responses in budding yeast
Recognition of the importance of cell-to-cell variability in cellular decision-making and a
growing interest in stochastic modeling of cellular processes has led to an increased …
growing interest in stochastic modeling of cellular processes has led to an increased …
Age-dependent deterioration of nuclear pore assembly in mitotic cells decreases transport dynamics
Nuclear transport is facilitated by the Nuclear Pore Complex (NPC) and is essential for life in
eukaryotes. The NPC is a long-lived and exceptionally large structure. We asked whether …
eukaryotes. The NPC is a long-lived and exceptionally large structure. We asked whether …
Early telomerase inactivation accelerates aging independently of telomere length
Telomerase is required for long-term telomere maintenance and protection. Using single
budding yeast mother cell analyses we found that, even early after telomerase inactivation …
budding yeast mother cell analyses we found that, even early after telomerase inactivation …
[HTML][HTML] Aging yeast cells undergo a sharp entry into senescence unrelated to the loss of mitochondrial membrane potential
S Fehrmann, C Paoletti, Y Goulev, A Ungureanu… - Cell reports, 2013 - cell.com
In budding yeast, a mother cell can produce a finite number of daughter cells before it stops
dividing and dies. Such entry into senescence is thought to result from a progressive decline …
dividing and dies. Such entry into senescence is thought to result from a progressive decline …
A new experimental platform facilitates assessment of the transcriptional and chromatin landscapes of aging yeast
Replicative aging of Saccharomyces cerevisiae is an established model system for
eukaryotic cellular aging. A limitation in yeast lifespan studies has been the difficulty of …
eukaryotic cellular aging. A limitation in yeast lifespan studies has been the difficulty of …