CRISPR–Cas systems provide resistance against foreign mobile genetic elements and have
a wide range of genome editing and biotechnological applications. In this Review, we …

In bacteria and archaea, clustered regularly interspaced short palindromic repeats
(CRISPR) and CRISPR-associated (Cas) proteins constitute an adaptive immune system …

Many bacteria and archaea have the unique ability to heritably alter their genomes by
incorporating small fragments of foreign DNA, called spacers, into CRISPR loci. Once …

Prokaryotes have developed numerous defense strategies to combat the constant threat
posed by the diverse genetic parasites that endanger them. Clustered regularly interspaced …

Although dynamics underlie many biological processes, our ability to robustly and
accurately profile time-varying biological signals and regulatory programs remains limited …

Toxoplasma gondii is an opportunistic pathogen widely distributed within the world, poses a
huge threat to human health, and causes significant economic losses to the livestock …

The CRISPR-Cas systems of bacterial and archaeal adaptive immunity consist of direct
repeat arrays separated by unique spacers and multiple CRISPR-associated (cas) genes …

Vibrio parahaemolyticus is a major cause of seafood-associated food poisoning. It is of great
significance to develop an accurate, simple and cost-effective method to identify infected …

Clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated
protein (Cas) systems, especially type II (Cas9) systems, have been widely used in …

Recognition and repression of RNA targets by Argonaute proteins guided by small RNAs is
the essence of RNA interference in eukaryotes. Argonaute proteins with diverse structures …