Drug delivery to the central nervous system
Despite the rising global incidence of central nervous system (CNS) disorders, CNS drug
development remains challenging, with high costs, long pathways to clinical use and high …
development remains challenging, with high costs, long pathways to clinical use and high …
Ferroptosis in cancer treatment: another way to Rome
Y Wu, C Yu, M Luo, C Cen, J Qiu, S Zhang… - Frontiers in oncology, 2020 - frontiersin.org
Ferroptosis is a newly described type of programmed cell death and intensively related to
both maintaining homeostasis and the development of diseases, especially cancers …
both maintaining homeostasis and the development of diseases, especially cancers …
Chiral metal-organic frameworks incorporating nanozymes as neuroinflammation inhibitors for managing Parkinson's disease
Nanomedicine-based anti-neuroinflammation strategy has become a promising dawn of
Parkinson's disease (PD) treatment. However, there are significant gaps in our …
Parkinson's disease (PD) treatment. However, there are significant gaps in our …
Mitochondrial ferritin attenuates cerebral ischaemia/reperfusion injury by inhibiting ferroptosis
P Wang, Y Cui, Q Ren, B Yan, Y Zhao, P Yu… - Cell death & …, 2021 - nature.com
Ischaemic stroke is becoming the most common cerebral disease in aging populations, but
the underlying molecular mechanism of the disease has not yet been fully elucidated …
the underlying molecular mechanism of the disease has not yet been fully elucidated …
Chiral Molecule-mediated Porous CuxO Nanoparticle Clusters with Antioxidation Activity for Ameliorating Parkinson's Disease
Reactive oxygen species (ROS)-mediated mitochondrial dysfunction is one of the major
pathological mechanisms of Parkinson's disease. Using inorganic nanomaterials to …
pathological mechanisms of Parkinson's disease. Using inorganic nanomaterials to …
Cellular iron metabolism and regulation
G Gao, J Li, Y Zhang, YZ Chang - Brain iron metabolism and CNS …, 2019 - Springer
Iron is an essential trace element in the human body, but excess iron is toxic as it contributes
to oxidative damage. To keep iron concentration within the optimal physiologic range, iron …
to oxidative damage. To keep iron concentration within the optimal physiologic range, iron …
Rethinking CRITID procedure of brain targeting drug delivery: circulation, blood brain barrier recognition, intracellular transport, diseased cell targeting, internalization …
The past decades have witnessed great progress in nanoparticle (NP)‐based brain‐
targeting drug delivery systems, while their therapeutic potentials are yet to be fully exploited …
targeting drug delivery systems, while their therapeutic potentials are yet to be fully exploited …
Promoting angiogenesis in oxidative diabetic wound microenvironment using a nanozyme-reinforced self-protecting hydrogel
Impaired diabetic wound healing represents a devastating and rapidly growing clinical
problem associated with high morbidity, mortality, and recurrence rates. Engineering …
problem associated with high morbidity, mortality, and recurrence rates. Engineering …
Engineered nanoerythrocytes alleviate central nervous system inflammation by regulating the polarization of inflammatory microglia
N Yin, Y Zhao, C Liu, Y Yang, ZH Wang… - Advanced …, 2022 - Wiley Online Library
Microglial polarization is one of the most promising therapeutic strategies for multiple central
nervous system (CNS) disorders. However, safe, effective, and controllable microglial …
nervous system (CNS) disorders. However, safe, effective, and controllable microglial …
Nanoparticle-induced ferroptosis: detection methods, mechanisms and applications
Although ferroptosis is an iron-dependent cell death mechanism involved in the
development of some severe diseases (eg, Parkinsonian syndrome, stroke and tumours) …
development of some severe diseases (eg, Parkinsonian syndrome, stroke and tumours) …