Type 2 diabetes is a metabolic, chronic disorder characterized by insulin resistance and
elevated blood glucose levels. Although a large drug portfolio exists to keep the blood …

TCF7L2 is the most potent locus for type 2 diabetes (T2D) risk and the first locus to have
been robustly reported by genomic linkage studies. TCF7L2 is a transcription factor that …

The evolutionarily conserved Wnt signaling pathway plays a central role in development and
adult tissue homeostasis across species. Wnt proteins are secreted, lipid-modified signaling …

Despite recent improvements in management of idiopathic pulmonary arterial hypertension,
mortality remains high. Understanding the alterations in the transcriptome–phenotype of the …

Cells in different tissues, including endocrine cells in the pancreas, live in complex
microenvironments that are rich in cellular and acellular components. Intricate interactions …

Insulin-producing β-cells constitute the majority of the cells in the pancreatic islets.
Dysfunction of these cells is a key factor in the loss of glucose regulation that characterizes …

The islets of Langerhans or pancreatic islets are pivotal in the control of blood glucose and
are complex microorgans embedded within the larger volume of the exocrine pancreas …

Intrahepatic islet transplantation is a promising β-cell replacement strategy for the treatment
of type 1 diabetes. Instant blood-mediated inflammatory reactions, acute inflammatory storm …

While inflammation is beneficial for insulin secretion during homeostasis, its transformation
adversely affects β cells and contributes to diabetes. However, the regulation of islet …

Pancreatic islets are endocrine organs that depend on their microvasculature to function.
Along with endothelial cells, pericytes comprise the islet microvascular network. These …