Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …

Although more studies are demonstrating that a father's environment can influence child
health and disease, the molecular mechanisms underlying non-genetic inheritance remain …

Objective Parental environmental exposures can strongly influence descendant risks for
adult disease. How paternal obesity changes the sperm chromatin leading to the acquisition …

Background: The organochlorine dichlorodiphenyltrichloroethane (DDT) is banned
worldwide owing to its negative health effects. It is exceptionally used as an insecticide for …

The mammalian genome undergoes extensive epigenetic reprogramming twice during
development, once during gestation when primordial germ cells (PGCs) are specified from …

Development of primordial germ cells (PGCs) is required for reproduction. During PGC
development in mammals, major epigenetic remodeling occurs, which is hypothesized to …

The paternal germline contains a plethora of information that extends beyond DNA.
Packaged within the sperm cell is a wealth of epigenetic information, including DNA …

Dynamic chromatin accessibility regulates stem cell fate determination and tissue
homeostasis via controlling gene expression. As a histone‐modifying enzyme that …

Background Non-genetic disease inheritance and offspring phenotype are substantially
influenced by germline epigenetic programming, including genomic imprinting. Loss of …

Abstract The field of Developmental Origins of Health and Disease (DOHaD) has primarily
focused on maternal programming of offspring health. However, emerging evidence …